RAB25_BOVIN
ID RAB25_BOVIN Reviewed; 213 AA.
AC Q58DW6; Q0VCM9;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Ras-related protein Rab-25;
DE Flags: Precursor;
GN Name=RAB25;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal lung;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the regulation of cell survival. Promotes
CC invasive migration of cells in which it functions to localize and
CC maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia.
CC Involved in the regulation of epithelial morphogenesis through the
CC control of CLDN4 expression and localization at tight junctions (By
CC similarity). May selectively regulate the apical recycling pathway.
CC Together with MYO5B regulates transcytosis (By similarity).
CC {ECO:0000250|UniProtKB:E2RQ15, ECO:0000250|UniProtKB:P46629,
CC ECO:0000250|UniProtKB:P57735, ECO:0000250|UniProtKB:Q9WTL2}.
CC -!- SUBUNIT: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4.
CC Interacts (via the hypervariable C-terminal region) with ITGB1 (via the
CC cytoplasmic region); the interaction is GTP-dependent. Interacts with
CC ITGAV. Associates with the integrin alpha-V/beta-1 heterodimer.
CC {ECO:0000250|UniProtKB:P57735}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection,
CC pseudopodium membrane {ECO:0000250|UniProtKB:P57735}. Cytoplasmic
CC vesicle {ECO:0000250|UniProtKB:P57735}. Note=Colocalizes with integrin
CC alpha-V/beta-1 in vesicles at the pseudopodial tips.
CC {ECO:0000250|UniProtKB:P57735}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; BT021481; AAX46328.1; -; mRNA.
DR EMBL; BC120091; AAI20092.1; -; mRNA.
DR RefSeq; NP_001017936.1; NM_001017936.1.
DR AlphaFoldDB; Q58DW6; -.
DR SMR; Q58DW6; -.
DR STRING; 9913.ENSBTAP00000025170; -.
DR PaxDb; Q58DW6; -.
DR PRIDE; Q58DW6; -.
DR Ensembl; ENSBTAT00000025170; ENSBTAP00000025170; ENSBTAG00000018914.
DR GeneID; 506482; -.
DR KEGG; bta:506482; -.
DR CTD; 57111; -.
DR VEuPathDB; HostDB:ENSBTAG00000018914; -.
DR VGNC; VGNC:33632; RAB25.
DR eggNOG; KOG0087; Eukaryota.
DR GeneTree; ENSGT00940000158230; -.
DR HOGENOM; CLU_041217_23_0_1; -.
DR InParanoid; Q58DW6; -.
DR OMA; KRACCIN; -.
DR OrthoDB; 1133775at2759; -.
DR TreeFam; TF300099; -.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000018914; Expressed in surface of tongue and 78 other tissues.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0031143; C:pseudopodium; ISS:UniProtKB.
DR GO; GO:0031260; C:pseudopodium membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0031489; F:myosin V binding; IEA:Ensembl.
DR GO; GO:0003382; P:epithelial cell morphogenesis; ISS:UniProtKB.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0031268; P:pseudopodium organization; ISS:UniProtKB.
DR GO; GO:0060627; P:regulation of vesicle-mediated transport; IEA:Ensembl.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell projection; Cytoplasmic vesicle; GTP-binding;
KW Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..210
FT /note="Ras-related protein Rab-25"
FT /id="PRO_0000244429"
FT PROPEP 211..213
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000370773"
FT MOTIF 41..49
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 19..27
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 67..71
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 125..128
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 155..157
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 210
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000255"
FT LIPID 209
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 210
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT CONFLICT 191
FT /note="T -> I (in Ref. 2; AAI20092)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 213 AA; 23537 MW; 29ECDCE77E266B9B CRC64;
MGNRAEEDYN FVFKVVLIGE SGVGKTNLLS RFTRNEFSHD SRTTIGVEFS TRTVMLGTAA
IKAQIWDTAG LERYRAITSA YYRGAVGALL VFDLTKHQTY AVVERWLKEL YDHAEATIVV
MLVGNKSDLS QSREVPTEEA RMFAENNGLL FLETSALDST NVELAFETVL KEIFAKVSKQ
RQNNARTNAV TLGSGPAGQE LGPGEKRACC ISL
