ID   RAB26_BOVIN             Reviewed;         256 AA.
AC   Q29RR0;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Ras-related protein Rab-26;
GN   Name=RAB26;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in exocrine secretion: regulates the secretion
CC       of acinar granules in the parotid gland. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; BC114066; AAI14067.1; -; mRNA.
DR   RefSeq; NP_001039674.1; NM_001046209.1.
DR   AlphaFoldDB; Q29RR0; -.
DR   SMR; Q29RR0; -.
DR   STRING; 9913.ENSBTAP00000000348; -.
DR   PaxDb; Q29RR0; -.
DR   PRIDE; Q29RR0; -.
DR   Ensembl; ENSBTAT00000000348; ENSBTAP00000000348; ENSBTAG00000000279.
DR   GeneID; 515675; -.
DR   KEGG; bta:515675; -.
DR   CTD; 25837; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000279; -.
DR   VGNC; VGNC:33633; RAB26.
DR   eggNOG; KOG0083; Eukaryota.
DR   GeneTree; ENSGT00940000158558; -.
DR   HOGENOM; CLU_041217_10_1_1; -.
DR   InParanoid; Q29RR0; -.
DR   OMA; QEYAQDD; -.
DR   OrthoDB; 1018397at2759; -.
DR   TreeFam; TF323428; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000000279; Expressed in adenohypophysis and 102 other tissues.
DR   ExpressionAtlas; Q29RR0; baseline and differential.
DR   GO; GO:0098993; C:anchored component of synaptic vesicle membrane; IEA:Ensembl.
DR   GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR   GO; GO:0031226; C:intrinsic component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0019002; F:GMP binding; IEA:Ensembl.
DR   GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0035272; P:exocrine system development; ISS:UniProtKB.
DR   GO; GO:0043001; P:Golgi to plasma membrane protein transport; IEA:Ensembl.
DR   GO; GO:0045055; P:regulated exocytosis; IEA:Ensembl.
DR   GO; GO:0017157; P:regulation of exocytosis; ISS:UniProtKB.
DR   GO; GO:0099575; P:regulation of protein catabolic process at presynapse, modulating synaptic transmission; IEA:Ensembl.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding;
KW   Prenylation; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..256
FT                   /note="Ras-related protein Rab-26"
FT                   /id="PRO_0000239696"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           93..101
FT                   /note="Effector region"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        31..48
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         70..78
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         119..123
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         177..180
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         207..209
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   LIPID           253
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           254
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   256 AA;  27802 MW;  8E0381BB86AAEC0E CRC64;
     MSRKKTPKSK AGSAPATSAL PAANGPRPVR PGTARPGPEA PPNGPPQPGR SSVGGGGDFY
     DVAFKVMLVG DSGVGKTCLL VRFKDGAFLA GTFISTVGID FRNKVVDVDG MKVKLQIWDT
     AGQERFRSVT HAYYRDAHAL LLLYDVTNKA SFDSIQAWLT EIQEHAQDDV VLMLLGNKVD
     SAQERAVKRE DAEKLAKDYG LPFMETSAKT GLNVDLAFTA IAKELKQRHT KAPSEPRFQL
     HDYIKREGRG ASCCRP