ID   RAB28_BOVIN             Reviewed;         221 AA.
AC   Q3SWY9;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Ras-related protein Rab-28;
DE   Flags: Precursor;
GN   Name=RAB28;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       cilium basal body. Note=Expressed in the basal body and ciliary rootlet
CC       of the photoreceptors. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; BC104592; AAI04593.1; -; mRNA.
DR   RefSeq; NP_001029806.1; NM_001034634.1.
DR   AlphaFoldDB; Q3SWY9; -.
DR   SMR; Q3SWY9; -.
DR   BioGRID; 192596; 82.
DR   STRING; 9913.ENSBTAP00000004180; -.
DR   PaxDb; Q3SWY9; -.
DR   PRIDE; Q3SWY9; -.
DR   Ensembl; ENSBTAT00000004180; ENSBTAP00000004180; ENSBTAG00000003218.
DR   GeneID; 536021; -.
DR   KEGG; bta:536021; -.
DR   CTD; 9364; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003218; -.
DR   VGNC; VGNC:33635; RAB28.
DR   eggNOG; KOG0078; Eukaryota.
DR   GeneTree; ENSGT00940000161833; -.
DR   HOGENOM; CLU_041217_10_4_1; -.
DR   InParanoid; Q3SWY9; -.
DR   OMA; YIYGSHA; -.
DR   OrthoDB; 1144210at2759; -.
DR   TreeFam; TF313852; -.
DR   Proteomes; UP000009136; Chromosome 6.
DR   Bgee; ENSBTAG00000003218; Expressed in spermatid and 107 other tissues.
DR   ExpressionAtlas; Q3SWY9; baseline.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0035253; C:ciliary rootlet; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019003; F:GDP binding; ISS:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:1901998; P:toxin transport; IEA:Ensembl.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cell membrane; Cell projection; Cytoplasm; Cytoskeleton;
KW   GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding;
KW   Phosphoprotein; Prenylation; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P51157"
FT   CHAIN           2..218
FT                   /note="Ras-related protein Rab-28"
FT                   /id="PRO_0000260530"
FT   PROPEP          219..221
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000396720"
FT   MOTIF           41..49
FT                   /note="Effector region"
FT                   /evidence="ECO:0000250"
FT   BINDING         19..27
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         68..72
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         129..132
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         159..161
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:P51157"
FT   MOD_RES         8
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P51157"
FT   MOD_RES         218
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250"
FT   LIPID           218
FT                   /note="S-farnesyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   221 AA;  24743 MW;  9DFAC504247D4A46 CRC64;
     MSDSEEESLD RQLKIVVLGD GTSGKTSLAT CFAQETFGKQ YKQTIGLDFF LRRITLPGSL
     NVTLQVWDIG GQTIGGKMLD KYIYGAQGVL LVYDVTNYQS FENLEDWYSV VKKVSEESET
     QPLVALVGNK IDLEHMRTVK PEKHLRFCQE NGFSSHFVSA KTGDSVFLCF QKVAAEILGI
     KLNKAEIEQS QRVVKADIVN YNQEPMSRTV NPPRSSMCAV Q