RAB28_MOUSE
ID RAB28_MOUSE Reviewed; 221 AA.
AC Q99KL7;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Ras-related protein Rab-28;
DE Flags: Precursor;
GN Name=Rab28;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton,
CC cilium basal body. Note=Expressed in the basal body and ciliary rootlet
CC of the photoreceptors. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; BC004580; AAH04580.1; -; mRNA.
DR CCDS; CCDS19258.1; -.
DR RefSeq; NP_081571.1; NM_027295.3.
DR AlphaFoldDB; Q99KL7; -.
DR SMR; Q99KL7; -.
DR BioGRID; 221561; 1.
DR IntAct; Q99KL7; 3.
DR STRING; 10090.ENSMUSP00000031011; -.
DR iPTMnet; Q99KL7; -.
DR PhosphoSitePlus; Q99KL7; -.
DR EPD; Q99KL7; -.
DR MaxQB; Q99KL7; -.
DR PaxDb; Q99KL7; -.
DR PRIDE; Q99KL7; -.
DR ProteomicsDB; 300223; -.
DR ABCD; Q99KL7; 2 sequenced antibodies.
DR Antibodypedia; 22919; 125 antibodies from 27 providers.
DR DNASU; 100972; -.
DR Ensembl; ENSMUST00000031011; ENSMUSP00000031011; ENSMUSG00000029128.
DR GeneID; 100972; -.
DR KEGG; mmu:100972; -.
DR UCSC; uc008xha.1; mouse.
DR CTD; 9364; -.
DR MGI; MGI:1917285; Rab28.
DR VEuPathDB; HostDB:ENSMUSG00000029128; -.
DR eggNOG; KOG0078; Eukaryota.
DR GeneTree; ENSGT00940000161833; -.
DR InParanoid; Q99KL7; -.
DR OMA; YIYGSHA; -.
DR OrthoDB; 1144210at2759; -.
DR PhylomeDB; Q99KL7; -.
DR TreeFam; TF313852; -.
DR BioGRID-ORCS; 100972; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Rab28; mouse.
DR PRO; PR:Q99KL7; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q99KL7; protein.
DR Bgee; ENSMUSG00000029128; Expressed in embryonic brain and 264 other tissues.
DR ExpressionAtlas; Q99KL7; baseline and differential.
DR Genevisible; Q99KL7; MM.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0035253; C:ciliary rootlet; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019003; F:GDP binding; ISS:UniProtKB.
DR GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:1901998; P:toxin transport; IMP:MGI.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cell membrane; Cell projection; Cytoplasm; Cytoskeleton;
KW GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding;
KW Phosphoprotein; Prenylation; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P51157"
FT CHAIN 2..218
FT /note="Ras-related protein Rab-28"
FT /id="PRO_0000121228"
FT PROPEP 219..221
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000396722"
FT MOTIF 41..49
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 19..27
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 68..72
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 129..132
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 159..161
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:P51157"
FT MOD_RES 8
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P51157"
FT MOD_RES 218
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 218
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 221 AA; 24728 MW; 5520BD9CC0F78FB9 CRC64;
MSDSEEESQD RQLKIVVLGD GTSGKTSLAT CFAQETFGKQ YKQTIGLDFF LRRITLPGNL
NVTLQVWDIG GQTIGGKMLD KYIYGAQGIL LVYDITNYQS FENLEDWYSV VKTVSEESET
QPLVALVGNK IDLEHMRTVK ADKHLRFCQE NGFSSHFVSA KTGDSVFLCF QKVAAEILGI
KLNKAEIEQS QRVVKADIVN YNQEPLSRTV NPPRSSMCAV Q
