ID   RAB2A_MESAU             Reviewed;          60 AA.
AC   P86207;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   03-AUG-2022, entry version 20.
DE   RecName: Full=Ras-related protein Rab-2A {ECO:0000250|UniProtKB:P61019};
DE            EC=3.6.5.2 {ECO:0000250|UniProtKB:P53994};
DE   Flags: Fragments;
GN   Name=RAB2A {ECO:0000250|UniProtKB:P61019};
GN   Synonyms=RAB2 {ECO:0000250|UniProtKB:P61019};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=20400973; DOI=10.1038/aja.2010.19;
RA   Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.;
RT   "Glucose-regulated protein precursor (GRP78) and tumor rejection antigen
RT   (GP96) are unique to hamster caput epididymal spermatozoa.";
RL   Asian J. Androl. 12:344-355(2010).
CC   -!- FUNCTION: The small GTPases Rab are key regulators of intracellular
CC       membrane trafficking, from the formation of transport vesicles to their
CC       fusion with membranes. Rabs cycle between active GTP-bound and inactive
CC       GDP-bound states. In their active state, drive transport of vesicular
CC       carriers from donor organelles to acceptor organelles to regulate the
CC       membrane traffic that maintains organelle identity and morphology.
CC       Required for protein transport from the endoplasmic reticulum to the
CC       Golgi complex. Regulates the compacted morphology of the Golgi.
CC       {ECO:0000250|UniProtKB:P61019}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC         Evidence={ECO:0000250|UniProtKB:P53994};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC         Evidence={ECO:0000250|UniProtKB:P53994};
CC   -!- ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors
CC       (GEFs) which promote the exchange of bound GDP for free GTP, GTPase
CC       activating proteins (GAPs) which increase the GTP hydrolysis activity,
CC       and GDP dissociation inhibitors which inhibit the dissociation of the
CC       nucleotide from the GTPase. {ECO:0000250|UniProtKB:P61019}.
CC   -!- SUBUNIT: Interacts with PRKCI. Interacts with TRIP11 (By similarity).
CC       Interacts (in GTP-bound form) with GARIN1B (By similarity).
CC       {ECO:0000250|UniProtKB:P53994, ECO:0000250|UniProtKB:P61019}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate
CC       compartment membrane {ECO:0000250|UniProtKB:P61019}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:P61019}. Melanosome
CC       {ECO:0000250|UniProtKB:P61019}. Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:P61019}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:P61019}. Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:P61019}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:P61019}. Cytoplasmic vesicle, secretory vesicle,
CC       acrosome {ECO:0000250|UniProtKB:P53994}. Note=Localized in the Golgi
CC       apparatus in the round spermatids and in the acrosome in the elongating
CC       spermatid (By similarity). Identified by mass spectrometry in
CC       melanosome fractions from stage I to stage IV (By similarity).
CC       {ECO:0000250|UniProtKB:P53994, ECO:0000250|UniProtKB:P61019}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000255}.
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DR   AlphaFoldDB; P86207; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0007030; P:Golgi organization; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cytoplasmic vesicle; Endoplasmic reticulum; ER-Golgi transport;
KW   Golgi apparatus; GTP-binding; Hydrolase; Lipoprotein; Membrane;
KW   Nucleotide-binding; Protein transport; Reference proteome; Transport.
FT   CHAIN           <1..>60
FT                   /note="Ras-related protein Rab-2A"
FT                   /id="PRO_0000394299"
FT   MOTIF           16..24
FT                   /note="Effector region"
FT                   /evidence="ECO:0000250|UniProtKB:P61019"
FT   NON_CONS        27..28
FT                   /evidence="ECO:0000305"
FT   NON_CONS        41..42
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         60
SQ   SEQUENCE   60 AA;  6689 MW;  4C4CAA1AF082BD7C CRC64;
     SCLLLQFTDK RFQPVHDLTI GVEFGARGAA GALLVYDITR RTASNVEEAF INTAKEIYEK