ID   RAB30_BOVIN             Reviewed;         203 AA.
AC   Q17QB7;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Ras-related protein Rab-30;
DE   Flags: Precursor;
GN   Name=RAB30;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The small GTPases Rab are key regulators of intracellular
CC       membrane trafficking, from the formation of transport vesicles to their
CC       fusion with membranes. Rabs cycle between an inactive GDP-bound form
CC       and an active GTP-bound form that is able to recruit to membranes
CC       different set of downstream effectors directly responsible for vesicle
CC       formation, movement, tethering and fusion (By similarity). Required for
CC       maintaining the structural integrity of the Golgi apparatus, possibly
CC       by mediating interactions with cytoplasmic scaffolding proteins (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Lipid-anchor
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus, trans-
CC       Golgi network {ECO:0000250}. Cytoplasm {ECO:0000250}. Golgi apparatus
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; BC118448; AAI18449.1; -; mRNA.
DR   RefSeq; NP_001069697.1; NM_001076229.2.
DR   RefSeq; XP_005226772.1; XM_005226715.3.
DR   RefSeq; XP_010819144.1; XM_010820842.2.
DR   RefSeq; XP_015316622.1; XM_015461136.1.
DR   AlphaFoldDB; Q17QB7; -.
DR   SMR; Q17QB7; -.
DR   STRING; 9913.ENSBTAP00000003135; -.
DR   PaxDb; Q17QB7; -.
DR   PRIDE; Q17QB7; -.
DR   Ensembl; ENSBTAT00000003135; ENSBTAP00000003135; ENSBTAG00000002417.
DR   Ensembl; ENSBTAT00000072775; ENSBTAP00000067338; ENSBTAG00000002417.
DR   GeneID; 540583; -.
DR   KEGG; bta:540583; -.
DR   CTD; 27314; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002417; -.
DR   VGNC; VGNC:33639; RAB30.
DR   eggNOG; KOG0095; Eukaryota.
DR   GeneTree; ENSGT00940000156875; -.
DR   HOGENOM; CLU_041217_10_1_1; -.
DR   InParanoid; Q17QB7; -.
DR   OMA; VYDVSCQ; -.
DR   OrthoDB; 1149105at2759; -.
DR   TreeFam; TF300097; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000002417; Expressed in cumulus cell and 109 other tissues.
DR   ExpressionAtlas; Q17QB7; baseline and differential.
DR   GO; GO:0005801; C:cis-Golgi network; ISS:UniProtKB.
DR   GO; GO:0031985; C:Golgi cisterna; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007030; P:Golgi organization; ISS:UniProtKB.
DR   GO; GO:0032482; P:Rab protein signal transduction; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   CDD; cd04114; Rab30; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR041820; Rab30.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Golgi apparatus; GTP-binding; Lipoprotein; Membrane;
KW   Methylation; Nucleotide-binding; Prenylation; Reference proteome.
FT   CHAIN           1..200
FT                   /note="Ras-related protein Rab-30"
FT                   /id="PRO_0000252672"
FT   PROPEP          201..203
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000370825"
FT   MOTIF           38..46
FT                   /note="Effector region"
FT                   /evidence="ECO:0000250"
FT   BINDING         16..23
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         64..68
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         122..125
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         200
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000255"
FT   LIPID           199
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           200
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   203 AA;  23058 MW;  935E56DBD48DD7C2 CRC64;
     MSMEDYDFLF KIVLIGNAGV GKTCLVRRFT QGLFPPGQGA TIGVDFMIKT VEINGEKVKL
     QIWDTAGQER FRSITQSYYR SANALILTYD ITCEESFRCL PEWLREIEQY ASNKVITVLV
     GNKIDLAERR EVSQQRAEEF SEAQDMYYLE TSAKESDNVE KLFLDLACRL ISEARQNTLV
     NNVSSPLPGE GKSISYLTCC NFN