ID   RAB33_CAEEL             Reviewed;         307 AA.
AC   Q20365; Q94154;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 158.
DE   RecName: Full=Ras-related protein Rab-33;
GN   Name=rab-33; ORFNames=F43D9.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 154-219.
RA   Nonet M.L., Staunton J.E., Kilgard M.P., Fergestad T., Jorgensen E.,
RA   Hartweig E., Horvitz H.R., Meyer B.J.;
RL   Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; Z35640; CAA84705.1; -; Genomic_DNA.
DR   EMBL; U68264; AAB16979.1; -; mRNA.
DR   PIR; T22128; T22128.
DR   RefSeq; NP_499314.1; NM_066913.4.
DR   AlphaFoldDB; Q20365; -.
DR   SMR; Q20365; -.
DR   BioGRID; 41661; 2.
DR   IntAct; Q20365; 2.
DR   STRING; 6239.F43D9.2; -.
DR   EPD; Q20365; -.
DR   PaxDb; Q20365; -.
DR   EnsemblMetazoa; F43D9.2.1; F43D9.2.1; WBGene00004283.
DR   GeneID; 176470; -.
DR   KEGG; cel:CELE_F43D9.2; -.
DR   UCSC; F43D9.2; c. elegans.
DR   CTD; 176470; -.
DR   WormBase; F43D9.2; CE00992; WBGene00004283; rab-33.
DR   eggNOG; KOG0084; Eukaryota.
DR   GeneTree; ENSGT00940000168608; -.
DR   HOGENOM; CLU_041217_10_3_1; -.
DR   InParanoid; Q20365; -.
DR   OMA; WNQREQE; -.
DR   OrthoDB; 1340129at2759; -.
DR   PhylomeDB; Q20365; -.
DR   Reactome; R-CEL-6811438; Intra-Golgi traffic.
DR   Reactome; R-CEL-8873719; RAB geranylgeranylation.
DR   PRO; PR:Q20365; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00004283; Expressed in adult organism and 4 other tissues.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0032482; P:Rab protein signal transduction; IEA:InterPro.
DR   CDD; cd04115; Rab33B_Rab33A; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR041822; Rab33A/B.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding;
KW   Prenylation; Reference proteome.
FT   CHAIN           1..307
FT                   /note="Ras-related protein Rab-33"
FT                   /id="PRO_0000121242"
FT   REGION          19..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           129..137
FT                   /note="Effector region"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        44..77
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         107..114
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         155..159
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         217..220
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   LIPID           306
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000255"
FT   LIPID           307
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   307 AA;  34344 MW;  1B23B78F7D7ADFE0 CRC64;
     MSEHHVNIPA PQFSTYATVI DPPKHVTATH PDELTTASHP QPTHPSAPQD PSPAVPSTPV
     RVPYPTAPPP IPPAPEAVTA GPKKMALAPS STKTYKQKRT FKVIIVGNAA VGKTCLSFRF
     CCGRFPEHTE ATIGVDFRER SCVIENELLR VQLWDTAGQE RYRQSIVAHY YRNVNAVVFV
     YDVTCRESFN DLALWIKECE KHGLVGDSEV PRILIGNKCD VECTNRVSTD EAQMFADRNN
     MALFETSAKL ASEADHVESI FLTLLHKLQQ SKPMHVQSQD ERHQKEQERL ILKANETENV
     EEEGFCC