ID   RAB33_CIOIN             Reviewed;         218 AA.
AC   P91580;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Putative Ras-related protein Rab-33;
GN   ORFNames=COS41.2;
OS   Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC   Cionidae; Ciona.
OX   NCBI_TaxID=7719;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bird A.P., Clark V., Jones S.J.M., Leitgeb S., Dobson R., Tweedie S.;
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; Z83760; CAB06046.1; -; Genomic_DNA.
DR   PIR; T31656; T31656.
DR   AlphaFoldDB; P91580; -.
DR   SMR; P91580; -.
DR   STRING; 7719.XP_002125159.1; -.
DR   PRIDE; P91580; -.
DR   eggNOG; KOG0084; Eukaryota.
DR   InParanoid; P91580; -.
DR   Proteomes; UP000008144; Unassembled WGS sequence.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0032482; P:Rab protein signal transduction; IEA:InterPro.
DR   CDD; cd04115; Rab33B_Rab33A; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR041822; Rab33A/B.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation;
KW   Nucleotide-binding; Prenylation; Reference proteome.
FT   CHAIN           1..218
FT                   /note="Putative Ras-related protein Rab-33"
FT                   /id="PRO_0000121241"
FT   MOTIF           44..52
FT                   /note="Effector region"
FT                   /evidence="ECO:0000250"
FT   BINDING         22..29
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         70..74
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         131..134
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         218
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250"
FT   LIPID           216
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           218
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   218 AA;  24618 MW;  5A6F0487A3755BC9 CRC64;
     MLQSGEGSPT LPKRVFKIIV IGDSDVGKTC LTYRFCTGKF PEKTEATIGV DFRERTLDID
     GEQIKLQLWD TAGQERFRKS MVPHYYRNVH AVVFTYDVTK GRSFQGLPSW IEECERYSLN
     ASEIPRILVG NKCDLKDQAE VDTNSATRFA DANSMPLFET SAKADSEMGN IEAIFLTVAH
     KLKSQKPMMK QDYPNMKRAT VLSVDKEVLR TNEAPCSC