RAB34_PIG
ID RAB34_PIG Reviewed; 259 AA.
AC Q06AU4;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Ras-related protein Rab-34;
GN Name=RAB34;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Liu G.Y.;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transport protein involved in the redistribution of lysosomes
CC to the peri-Golgi region (By similarity). Plays a role in the
CC maturation of phagosomes that engulf pathogens, such as S.aureus and
CC M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes
CC (By similarity). Acts also as a positive regulator of hedgehog
CC signaling and regulates ciliary function (By similarity).
CC {ECO:0000250|UniProtKB:Q64008, ECO:0000250|UniProtKB:Q9BZG1}.
CC -!- SUBUNIT: Interacts with RILP. {ECO:0000250|UniProtKB:Q9BZG1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q64008}. Golgi
CC apparatus {ECO:0000250|UniProtKB:Q64008}. Cytoplasmic vesicle,
CC phagosome {ECO:0000250|UniProtKB:Q9BZG1}. Cytoplasmic vesicle,
CC phagosome membrane {ECO:0000250|UniProtKB:Q9BZG1}; Lipid-anchor
CC {ECO:0000250|UniProtKB:Q9BZG1}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q9BZG1}. Cell projection, cilium
CC {ECO:0000250|UniProtKB:Q64008}. Note=Recruited to phagosomes containing
CC S.aureus or Mycobacterium. {ECO:0000250|UniProtKB:Q9BZG1}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; DQ917631; ABI97176.1; -; mRNA.
DR RefSeq; NP_001116650.1; NM_001123178.1.
DR RefSeq; XP_013845420.1; XM_013989966.1.
DR RefSeq; XP_013845421.1; XM_013989967.1.
DR AlphaFoldDB; Q06AU4; -.
DR SMR; Q06AU4; -.
DR STRING; 9823.ENSSSCP00000018828; -.
DR PaxDb; Q06AU4; -.
DR PeptideAtlas; Q06AU4; -.
DR PRIDE; Q06AU4; -.
DR Ensembl; ENSSSCT00000019341; ENSSSCP00000018828; ENSSSCG00000017769.
DR Ensembl; ENSSSCT00005067726; ENSSSCP00005042093; ENSSSCG00005041928.
DR Ensembl; ENSSSCT00005067771; ENSSSCP00005042118; ENSSSCG00005041928.
DR Ensembl; ENSSSCT00015097793; ENSSSCP00015040197; ENSSSCG00015071811.
DR Ensembl; ENSSSCT00025071654; ENSSSCP00025031038; ENSSSCG00025052298.
DR Ensembl; ENSSSCT00030082377; ENSSSCP00030037829; ENSSSCG00030058966.
DR Ensembl; ENSSSCT00035081506; ENSSSCP00035033728; ENSSSCG00035060685.
DR Ensembl; ENSSSCT00040060798; ENSSSCP00040025537; ENSSSCG00040045190.
DR Ensembl; ENSSSCT00045052430; ENSSSCP00045036460; ENSSSCG00045030278.
DR Ensembl; ENSSSCT00045052549; ENSSSCP00045036541; ENSSSCG00045030278.
DR Ensembl; ENSSSCT00055004350; ENSSSCP00055003336; ENSSSCG00055002223.
DR Ensembl; ENSSSCT00055004362; ENSSSCP00055003347; ENSSSCG00055002223.
DR Ensembl; ENSSSCT00060091661; ENSSSCP00060039618; ENSSSCG00060067189.
DR Ensembl; ENSSSCT00060091980; ENSSSCP00060039741; ENSSSCG00060067189.
DR Ensembl; ENSSSCT00065066239; ENSSSCP00065028705; ENSSSCG00065048406.
DR Ensembl; ENSSSCT00065066468; ENSSSCP00065028803; ENSSSCG00065048406.
DR Ensembl; ENSSSCT00070022775; ENSSSCP00070018835; ENSSSCG00070011675.
DR GeneID; 100144491; -.
DR KEGG; ssc:100144491; -.
DR CTD; 83871; -.
DR VGNC; VGNC:98258; RAB34.
DR eggNOG; KOG0094; Eukaryota.
DR GeneTree; ENSGT00940000159645; -.
DR HOGENOM; CLU_041217_22_0_1; -.
DR InParanoid; Q06AU4; -.
DR OMA; KKKQANC; -.
DR OrthoDB; 1048146at2759; -.
DR TreeFam; TF326626; -.
DR Proteomes; UP000008227; Chromosome 12.
DR Proteomes; UP000314985; Chromosome 12.
DR Bgee; ENSSSCG00000017769; Expressed in forelimb bud and 37 other tissues.
DR ExpressionAtlas; Q06AU4; baseline.
DR Genevisible; Q06AU4; SS.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0031985; C:Golgi cisterna; IBA:GO_Central.
DR GO; GO:0045335; C:phagocytic vesicle; ISS:UniProtKB.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0043001; P:Golgi to plasma membrane protein transport; IBA:GO_Central.
DR GO; GO:0090382; P:phagosome maturation; ISS:UniProtKB.
DR GO; GO:0090385; P:phagosome-lysosome fusion; ISS:UniProtKB.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISS:UniProtKB.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cell projection; Cilium biogenesis/degradation; Cytoplasm;
KW Cytoplasmic vesicle; Golgi apparatus; GTP-binding; Lipoprotein; Membrane;
KW Nucleotide-binding; Phosphoprotein; Prenylation; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..259
FT /note="Ras-related protein Rab-34"
FT /id="PRO_0000262880"
FT MOTIF 81..89
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 59..66
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 107..111
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 166..169
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9BZG1"
FT MOD_RES 241
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BZG1"
FT MOD_RES 244
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BZG1"
FT LIPID 257
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 258
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 259 AA; 29115 MW; D35E0E58845F5ABE CRC64;
MNILAPVRRD RVLAELPQCL RKEAALHVRK DFHPRVTCAC QEHRTGTVGF KISKVIVVGD
LSVGKTCLIN RFCKDTFDKN YKATIGVDFE MERFEVLGVP FSLQLWDTAG QERFKCIAST
YYRGAQAIII VFNLNDVASL EHTKQWLADA LKENDPSSVL LFLVGSKKDL STPAQYVLME
KDALKVAHEM KAEYWAVSSL TGENVREFFF RVAALTFEAN VLAELEKSGS RRIGDVVRLN
SDDSNLYLTA SKKKPACCP
