RAB34_RAT
ID RAB34_RAT Reviewed; 259 AA.
AC Q5U1Y1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Ras-related protein Rab-34;
GN Name=Rab34;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transport protein involved in the redistribution of lysosomes
CC to the peri-Golgi region (By similarity). Plays a role in the
CC maturation of phagosomes that engulf pathogens, such as S.aureus and
CC M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes
CC (By similarity). Acts also as a positive regulator of hedgehog
CC signaling and regulates ciliary function (By similarity).
CC {ECO:0000250|UniProtKB:Q64008, ECO:0000250|UniProtKB:Q9BZG1}.
CC -!- SUBUNIT: Interacts with RILP. {ECO:0000250|UniProtKB:Q9BZG1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q64008}. Golgi
CC apparatus {ECO:0000250|UniProtKB:Q64008}. Cytoplasmic vesicle,
CC phagosome {ECO:0000250|UniProtKB:Q9BZG1}. Cytoplasmic vesicle,
CC phagosome membrane {ECO:0000250|UniProtKB:Q9BZG1}; Lipid-anchor
CC {ECO:0000250|UniProtKB:Q9BZG1}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q9BZG1}. Cell projection, cilium
CC {ECO:0000250|UniProtKB:Q64008}. Note=Recruited to phagosomes containing
CC S.aureus or Mycobacterium. {ECO:0000250|UniProtKB:Q9BZG1}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; BC086400; AAH86400.1; -; mRNA.
DR RefSeq; NP_001012140.1; NM_001012140.1.
DR AlphaFoldDB; Q5U1Y1; -.
DR SMR; Q5U1Y1; -.
DR IntAct; Q5U1Y1; 1.
DR STRING; 10116.ENSRNOP00000036566; -.
DR iPTMnet; Q5U1Y1; -.
DR PhosphoSitePlus; Q5U1Y1; -.
DR jPOST; Q5U1Y1; -.
DR PaxDb; Q5U1Y1; -.
DR PRIDE; Q5U1Y1; -.
DR Ensembl; ENSRNOT00000037016; ENSRNOP00000036566; ENSRNOG00000023375.
DR GeneID; 360571; -.
DR KEGG; rno:360571; -.
DR CTD; 83871; -.
DR RGD; 1305058; Rab34.
DR eggNOG; KOG0094; Eukaryota.
DR InParanoid; Q5U1Y1; -.
DR OrthoDB; 1048146at2759; -.
DR PhylomeDB; Q5U1Y1; -.
DR TreeFam; TF326626; -.
DR Reactome; R-RNO-8873719; RAB geranylgeranylation.
DR PRO; PR:Q5U1Y1; -.
DR Proteomes; UP000002494; Chromosome 10.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISO:RGD.
DR GO; GO:0005769; C:early endosome; ISO:RGD.
DR GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR GO; GO:0031985; C:Golgi cisterna; ISO:RGD.
DR GO; GO:0005795; C:Golgi stack; ISO:RGD.
DR GO; GO:0005770; C:late endosome; ISO:RGD.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR GO; GO:0045335; C:phagocytic vesicle; ISS:UniProtKB.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; ISO:RGD.
DR GO; GO:0031982; C:vesicle; ISO:RGD.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0030742; F:GTP-dependent protein binding; ISO:RGD.
DR GO; GO:0003924; F:GTPase activity; ISO:RGD.
DR GO; GO:0019001; F:guanyl nucleotide binding; ISO:RGD.
DR GO; GO:0031267; F:small GTPase binding; ISO:RGD.
DR GO; GO:0019882; P:antigen processing and presentation; ISO:RGD.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0071333; P:cellular response to glucose stimulus; IMP:ParkinsonsUK-UCL.
DR GO; GO:0006897; P:endocytosis; ISO:RGD.
DR GO; GO:0043001; P:Golgi to plasma membrane protein transport; ISO:RGD.
DR GO; GO:0007041; P:lysosomal transport; ISO:RGD.
DR GO; GO:0032418; P:lysosome localization; ISO:RGD.
DR GO; GO:0090382; P:phagosome maturation; ISS:UniProtKB.
DR GO; GO:0090385; P:phagosome-lysosome fusion; ISS:UniProtKB.
DR GO; GO:1900426; P:positive regulation of defense response to bacterium; ISO:RGD.
DR GO; GO:1905171; P:positive regulation of protein localization to phagocytic vesicle; ISO:RGD.
DR GO; GO:0050714; P:positive regulation of protein secretion; IMP:ParkinsonsUK-UCL.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISS:UniProtKB.
DR GO; GO:0072659; P:protein localization to plasma membrane; ISO:RGD.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cell projection; Cilium biogenesis/degradation; Cytoplasm;
KW Cytoplasmic vesicle; Golgi apparatus; GTP-binding; Lipoprotein; Membrane;
KW Nucleotide-binding; Phosphoprotein; Prenylation; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..259
FT /note="Ras-related protein Rab-34"
FT /id="PRO_0000315238"
FT MOTIF 81..89
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 59..66
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 107..111
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 166..169
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9BZG1"
FT MOD_RES 241
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BZG1"
FT LIPID 257
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 258
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 259 AA; 29103 MW; 17593A92727B8389 CRC64;
MNILAPVRRD RVLAELPQCL KKEAALHVRK DFHPRVTCAC QEHRTGTVGF KISKVIVVGD
LSVGKTCLIN RFCKDTFDKN YKATIGVDFE MERFEVLGVP FSLQLWDTAG QERFKCIAST
YYRGAQAIII VFNLNDVASL EHSKQWLADA LKENDPSNVL LFLVGSKKDL STPAQYSLME
KDALKVAQEI KAEYWSVSSL TGENVREFFF RVAALTFEAN VLAELEKSGS RHIGDVVRIN
SDDKNLYLTA SKKKATCCP
