RAB36_HUMAN
ID RAB36_HUMAN Reviewed; 333 AA.
AC O95755; Q2M390; Q7Z4A9; Q9UHP5;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2004, sequence version 2.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=Ras-related protein Rab-36;
GN Name=RAB36;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ASP-308.
RX PubMed=9920784; DOI=10.1006/bbrc.1998.9968;
RA Mori T., Fukuda Y., Kuroda H., Matsumura T., Ota S., Sugimoto T.,
RA Nakamura Y., Inazawa J.;
RT "Cloning and characterization of a novel Rab-family gene, Rab36, within the
RT region at 22q11.2 that is homozygously deleted in malignant rhabdoid
RT tumors.";
RL Biochem. Biophys. Res. Commun. 254:594-600(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=10607907; DOI=10.1016/s0378-1119(99)00456-4;
RA Zhou J.-Y., Fogelgren B., Wang Z., Roe B.A., Biegel J.A.;
RT "Isolation of genes from the rhabdoid tumor deletion region in chromosome
RT band 22q11.2.";
RL Gene 241:133-141(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Shen C., Zhong G., Zheng G., Li H., Zhou G., Ke R., Yu R., Lin L., Yang S.;
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Protein transport. Probably involved in vesicular traffic (By
CC similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC O95755; O75031: HSF2BP; NbExp=3; IntAct=EBI-12404625, EBI-7116203;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Lipid-anchor.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O95755-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O95755-2; Sequence=VSP_010143;
CC -!- TISSUE SPECIFICITY: Ubiquitously present in all tissues examined.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; AB023061; BAA75195.1; -; mRNA.
DR EMBL; AF133588; AAF02485.1; -; mRNA.
DR EMBL; AY336745; AAQ16115.1; -; mRNA.
DR EMBL; CR456553; CAG30439.1; -; mRNA.
DR EMBL; BC104989; AAI04990.1; -; mRNA.
DR EMBL; BC104991; AAI04992.1; -; mRNA.
DR RefSeq; NP_004905.2; NM_004914.3.
DR AlphaFoldDB; O95755; -.
DR SMR; O95755; -.
DR BioGRID; 114971; 3.
DR IntAct; O95755; 1.
DR STRING; 9606.ENSP00000263116; -.
DR iPTMnet; O95755; -.
DR PhosphoSitePlus; O95755; -.
DR BioMuta; RAB36; -.
DR REPRODUCTION-2DPAGE; O95755; -.
DR EPD; O95755; -.
DR jPOST; O95755; -.
DR MassIVE; O95755; -.
DR MaxQB; O95755; -.
DR PaxDb; O95755; -.
DR PeptideAtlas; O95755; -.
DR PRIDE; O95755; -.
DR ProteomicsDB; 51025; -. [O95755-1]
DR ProteomicsDB; 51026; -. [O95755-2]
DR TopDownProteomics; O95755-1; -. [O95755-1]
DR Antibodypedia; 23692; 113 antibodies from 23 providers.
DR DNASU; 9609; -.
DR Ensembl; ENST00000263116.8; ENSP00000263116.3; ENSG00000100228.14.
DR Ensembl; ENST00000341989.9; ENSP00000343494.5; ENSG00000100228.14.
DR GeneID; 9609; -.
DR KEGG; hsa:9609; -.
DR UCSC; uc002zwv.2; human. [O95755-1]
DR CTD; 9609; -.
DR DisGeNET; 9609; -.
DR GeneCards; RAB36; -.
DR HGNC; HGNC:9775; RAB36.
DR HPA; ENSG00000100228; Tissue enhanced (fallopian).
DR MIM; 605662; gene.
DR neXtProt; NX_O95755; -.
DR PharmGKB; PA34128; -.
DR VEuPathDB; HostDB:ENSG00000100228; -.
DR eggNOG; KOG0094; Eukaryota.
DR HOGENOM; CLU_041217_22_1_1; -.
DR InParanoid; O95755; -.
DR OMA; HRFCKNI; -.
DR OrthoDB; 1048146at2759; -.
DR PhylomeDB; O95755; -.
DR TreeFam; TF326626; -.
DR PathwayCommons; O95755; -.
DR Reactome; R-HSA-6811438; Intra-Golgi traffic.
DR Reactome; R-HSA-8873719; RAB geranylgeranylation.
DR SignaLink; O95755; -.
DR BioGRID-ORCS; 9609; 32 hits in 1073 CRISPR screens.
DR ChiTaRS; RAB36; human.
DR GeneWiki; RAB36; -.
DR GenomeRNAi; 9609; -.
DR Pharos; O95755; Tbio.
DR PRO; PR:O95755; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; O95755; protein.
DR Bgee; ENSG00000100228; Expressed in right uterine tube and 134 other tissues.
DR ExpressionAtlas; O95755; baseline and differential.
DR Genevisible; O95755; HS.
DR GO; GO:0005794; C:Golgi apparatus; TAS:ProtInc.
DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Golgi apparatus; GTP-binding; Lipoprotein; Membrane;
KW Nucleotide-binding; Prenylation; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..333
FT /note="Ras-related protein Rab-36"
FT /id="PRO_0000121248"
FT REGION 309..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 152..160
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 130..137
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 178..182
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 237..240
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT LIPID 332
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 333
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 121..142
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_010143"
FT VARIANT 50
FT /note="P -> L (in dbSNP:rs9624036)"
FT /id="VAR_034433"
FT VARIANT 308
FT /note="N -> D (in dbSNP:rs5759612)"
FT /evidence="ECO:0000269|PubMed:9920784"
FT /id="VAR_024189"
FT VARIANT 320
FT /note="E -> K (in dbSNP:rs9624038)"
FT /id="VAR_051715"
FT CONFLICT 42
FT /note="I -> N (in Ref. 3; AAQ16115)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 333 AA; 36322 MW; FFDD522F6DE40A2D CRC64;
MVIAGASWML GRAAASPTQT PPTTSTIRVA RRSRVALVAM VIAAAGSGGP GRAEPQLSQP
SLDCGRMRSS LTPLGPPVSR DRVIASFPKW YTPEACLQLR EHFHGQVSAA CQRRNTGTVG
LKLSKVVVVG DLYVGKTSLI HRFCKNVFDR DYKATIGVDF EIERFEIAGI PYSLQIWDTA
GQEKFKCIAS AYYRGAQVII TAFDLTDVQT LEHTRQWLED ALRENEAGSC FIFLVGTKKD
LLSGAACEQA EADAVHLARE MQAEYWSVSA KTGENVKAFF SRVAALAFEQ SVLQDLERQS
SARLQVGNGD LIQMEGSPPE TQESKRPSSL GCC
