RAB36_MOUSE
ID RAB36_MOUSE Reviewed; 267 AA.
AC Q8CAM5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Ras-related protein Rab-36;
GN Name=Rab36;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=16923123; DOI=10.1111/j.1365-2443.2006.00997.x;
RA Itoh T., Satoh M., Kanno E., Fukuda M.;
RT "Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing
RT proteins based on their Rab-binding activity.";
RL Genes Cells 11:1023-1037(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, Eye, and Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Protein transport. Probably involved in vesicular traffic (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Lipid-anchor.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; AB232632; BAF02894.1; -; mRNA.
DR EMBL; AK038445; BAC30001.1; -; mRNA.
DR EMBL; AK046113; BAE20653.1; -; mRNA.
DR EMBL; AK142025; BAE24917.1; -; mRNA.
DR EMBL; BC119094; AAI19095.1; -; mRNA.
DR EMBL; BC119098; AAI19099.1; -; mRNA.
DR CCDS; CCDS23923.2; -.
DR RefSeq; NP_084057.1; NM_029781.3.
DR RefSeq; XP_006514349.1; XM_006514286.1.
DR RefSeq; XP_006514350.1; XM_006514287.1.
DR RefSeq; XP_006514351.1; XM_006514288.1.
DR RefSeq; XP_006514352.1; XM_006514289.1.
DR RefSeq; XP_006514353.1; XM_006514290.1.
DR RefSeq; XP_006514354.1; XM_006514291.1.
DR RefSeq; XP_011241901.1; XM_011243599.1.
DR AlphaFoldDB; Q8CAM5; -.
DR SMR; Q8CAM5; -.
DR IntAct; Q8CAM5; 7.
DR STRING; 10090.ENSMUSP00000119399; -.
DR iPTMnet; Q8CAM5; -.
DR PhosphoSitePlus; Q8CAM5; -.
DR MaxQB; Q8CAM5; -.
DR PaxDb; Q8CAM5; -.
DR PRIDE; Q8CAM5; -.
DR ProteomicsDB; 253144; -.
DR Antibodypedia; 23692; 113 antibodies from 23 providers.
DR DNASU; 76877; -.
DR Ensembl; ENSMUST00000146440; ENSMUSP00000121693; ENSMUSG00000020175.
DR Ensembl; ENSMUST00000147802; ENSMUSP00000119399; ENSMUSG00000020175.
DR Ensembl; ENSMUST00000234625; ENSMUSP00000157124; ENSMUSG00000020175.
DR GeneID; 76877; -.
DR UCSC; uc007fpx.1; mouse.
DR CTD; 9609; -.
DR MGI; MGI:1924127; Rab36.
DR VEuPathDB; HostDB:ENSMUSG00000020175; -.
DR eggNOG; KOG0094; Eukaryota.
DR GeneTree; ENSGT00940000159687; -.
DR HOGENOM; CLU_041217_22_1_1; -.
DR InParanoid; Q8CAM5; -.
DR OMA; HRFCKNI; -.
DR OrthoDB; 1048146at2759; -.
DR PhylomeDB; Q8CAM5; -.
DR TreeFam; TF326626; -.
DR Reactome; R-MMU-6811438; Intra-Golgi traffic.
DR Reactome; R-MMU-8873719; RAB geranylgeranylation.
DR BioGRID-ORCS; 76877; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Rab36; mouse.
DR PRO; PR:Q8CAM5; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8CAM5; protein.
DR Bgee; ENSMUSG00000020175; Expressed in medial preoptic region and 160 other tissues.
DR ExpressionAtlas; Q8CAM5; baseline and differential.
DR Genevisible; Q8CAM5; MM.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding;
KW Prenylation; Protein transport; Reference proteome; Transport.
FT CHAIN 1..267
FT /note="Ras-related protein Rab-36"
FT /id="PRO_0000315237"
FT MOTIF 86..94
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 64..71
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 112..116
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 171..174
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT LIPID 266
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 267
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 267 AA; 29776 MW; E1D4B36A4BA598F0 CRC64;
MRSSWTPLGP PVSQDRIITS FPKWYTPDAC LQLKEHFHSR VSTACQHRNT GTAGLRLSKV
VVVGDLYVGK TSLIHRLCKN VFDHDYKATI GVDFEIERFE IAGIPYSLQI WDTAGQEKFK
CIASAYYRGA QVIITAFDLT DVQTLEHTRQ WLEDVLRENE AGSCFIFLVG TKKDLLSGAA
CEQAEAEAVH LANEMQAEYW SVSAKTGENV KAFFSRVAAL AFEQSVLQDL EKRPSTQSQV
GDGDGDLIRI EVPKTQENKR PPGLGCC
