RAB37_HUMAN
ID RAB37_HUMAN Reviewed; 223 AA.
AC Q96AX2; A8MXF5; A8MYT0; Q8IWA7;
DT 31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Ras-related protein Rab-37;
DE Flags: Precursor;
GN Name=RAB37;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
RC TISSUE=Thalamus, Thymus, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PROTEIN SEQUENCE OF 2-11, AND ACETYLATION AT THR-2.
RC TISSUE=Platelet;
RX PubMed=12665801; DOI=10.1038/nbt810;
RA Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R.,
RA Vandekerckhove J.;
RT "Exploring proteomes and analyzing protein processing by mass spectrometric
RT identification of sorted N-terminal peptides.";
RL Nat. Biotechnol. 21:566-569(2003).
CC -!- SUBUNIT: Interacts with RIMS1. {ECO:0000250}.
CC -!- INTERACTION:
CC Q96AX2; Q969L2: MAL2; NbExp=3; IntAct=EBI-748121, EBI-944295;
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle. Note=Secretory granules.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q96AX2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96AX2-2; Sequence=VSP_041268;
CC Name=3;
CC IsoId=Q96AX2-3; Sequence=VSP_043155;
CC Name=4;
CC IsoId=Q96AX2-4; Sequence=VSP_043156;
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; AK098068; BAC05227.1; -; mRNA.
DR EMBL; AK290202; BAF82891.1; -; mRNA.
DR EMBL; AK296172; BAH12272.1; -; mRNA.
DR EMBL; AK303442; BAH13962.1; -; mRNA.
DR EMBL; AC016888; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC064805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471099; EAW89180.1; -; Genomic_DNA.
DR EMBL; BC016615; AAH16615.1; -; mRNA.
DR EMBL; BC040547; AAH40547.1; -; mRNA.
DR CCDS; CCDS11703.1; -. [Q96AX2-2]
DR CCDS; CCDS32722.1; -. [Q96AX2-1]
DR CCDS; CCDS54161.1; -. [Q96AX2-3]
DR CCDS; CCDS54162.1; -. [Q96AX2-4]
DR RefSeq; NP_001006639.1; NM_001006638.2. [Q96AX2-1]
DR RefSeq; NP_001157461.1; NM_001163989.1. [Q96AX2-3]
DR RefSeq; NP_001157462.1; NM_001163990.1. [Q96AX2-4]
DR RefSeq; NP_001317400.1; NM_001330471.1.
DR RefSeq; NP_783865.1; NM_175738.4. [Q96AX2-2]
DR AlphaFoldDB; Q96AX2; -.
DR SMR; Q96AX2; -.
DR BioGRID; 130604; 11.
DR IntAct; Q96AX2; 5.
DR STRING; 9606.ENSP00000376390; -.
DR iPTMnet; Q96AX2; -.
DR PhosphoSitePlus; Q96AX2; -.
DR BioMuta; RAB37; -.
DR DMDM; 20139581; -.
DR jPOST; Q96AX2; -.
DR MassIVE; Q96AX2; -.
DR MaxQB; Q96AX2; -.
DR PaxDb; Q96AX2; -.
DR PeptideAtlas; Q96AX2; -.
DR PRIDE; Q96AX2; -.
DR ProteomicsDB; 76005; -. [Q96AX2-1]
DR ProteomicsDB; 76006; -. [Q96AX2-2]
DR ProteomicsDB; 76007; -. [Q96AX2-3]
DR ProteomicsDB; 76008; -. [Q96AX2-4]
DR Antibodypedia; 31994; 378 antibodies from 28 providers.
DR DNASU; 326624; -.
DR Ensembl; ENST00000392612.7; ENSP00000376388.3; ENSG00000172794.20. [Q96AX2-4]
DR Ensembl; ENST00000392613.10; ENSP00000376389.5; ENSG00000172794.20. [Q96AX2-1]
DR Ensembl; ENST00000392614.8; ENSP00000376390.4; ENSG00000172794.20. [Q96AX2-3]
DR Ensembl; ENST00000402449.8; ENSP00000383934.4; ENSG00000172794.20. [Q96AX2-2]
DR Ensembl; ENST00000481224.5; ENSP00000436563.1; ENSG00000172794.20. [Q96AX2-1]
DR Ensembl; ENST00000613645.1; ENSP00000483155.1; ENSG00000172794.20. [Q96AX2-1]
DR GeneID; 326624; -.
DR KEGG; hsa:326624; -.
DR MANE-Select; ENST00000392613.10; ENSP00000376389.5; NM_001006638.3; NP_001006639.1.
DR UCSC; uc002jlk.4; human. [Q96AX2-1]
DR CTD; 326624; -.
DR DisGeNET; 326624; -.
DR GeneCards; RAB37; -.
DR HGNC; HGNC:30268; RAB37.
DR HPA; ENSG00000172794; Tissue enhanced (bone marrow, brain, lymphoid tissue).
DR MIM; 609956; gene.
DR neXtProt; NX_Q96AX2; -.
DR OpenTargets; ENSG00000172794; -.
DR PharmGKB; PA134901093; -.
DR VEuPathDB; HostDB:ENSG00000172794; -.
DR eggNOG; KOG0083; Eukaryota.
DR GeneTree; ENSGT00940000158883; -.
DR InParanoid; Q96AX2; -.
DR OMA; AYYTTAY; -.
DR OrthoDB; 1018397at2759; -.
DR PhylomeDB; Q96AX2; -.
DR TreeFam; TF323428; -.
DR BRENDA; 3.6.5.2; 2681.
DR PathwayCommons; Q96AX2; -.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR Reactome; R-HSA-8873719; RAB geranylgeranylation.
DR SignaLink; Q96AX2; -.
DR BioGRID-ORCS; 326624; 8 hits in 1066 CRISPR screens.
DR ChiTaRS; RAB37; human.
DR GeneWiki; RAB37; -.
DR GenomeRNAi; 326624; -.
DR Pharos; Q96AX2; Tbio.
DR PRO; PR:Q96AX2; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q96AX2; protein.
DR Bgee; ENSG00000172794; Expressed in cerebellar hemisphere and 116 other tissues.
DR ExpressionAtlas; Q96AX2; baseline and differential.
DR Genevisible; Q96AX2; HS.
DR GO; GO:0035577; C:azurophil granule membrane; TAS:Reactome.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:UniProtKB.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0035579; C:specific granule membrane; TAS:Reactome.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Cytoplasmic vesicle;
KW Direct protein sequencing; GTP-binding; Lipoprotein; Methylation;
KW Nucleotide-binding; Prenylation; Protein transport; Reference proteome;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:12665801"
FT CHAIN 2..220
FT /note="Ras-related protein Rab-37"
FT /id="PRO_0000121249"
FT PROPEP 221..223
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000370828"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 59..67
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 36..43
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 85..89
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 143..146
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 2
FT /note="N-acetylthreonine"
FT /evidence="ECO:0000269|PubMed:12665801"
FT MOD_RES 220
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000255"
FT LIPID 219
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 220
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..68
FT /note="MTGTPGAVATRDGEAPERSPPCSPSYDLTGKVMLLGDTGVGKTCFLIQFKDG
FT AFLSGTFIATVGIDFR -> MDLQRPDSYQGGAGPDFNDHVLHKTILVGDSGVGKTSLL
FT VQFDQGKFIPGSFSATVGIGFT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_041268"
FT VAR_SEQ 1..30
FT /note="MTGTPGAVATRDGEAPERSPPCSPSYDLTG -> MWLMSEAHGAEPVLLREA
FT ARPFTQTLRLCVPSGNS (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043155"
FT VAR_SEQ 32..68
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043156"
FT VARIANT 188
FT /note="A -> P (in dbSNP:rs34215331)"
FT /id="VAR_034434"
SQ SEQUENCE 223 AA; 24815 MW; 5A7A4887BCBB84A8 CRC64;
MTGTPGAVAT RDGEAPERSP PCSPSYDLTG KVMLLGDTGV GKTCFLIQFK DGAFLSGTFI
ATVGIDFRNK VVTVDGVRVK LQIWDTAGQE RFRSVTHAYY RDAQALLLLY DITNKSSFDN
IRAWLTEIHE YAQRDVVIML LGNKADMSSE RVIRSEDGET LAREYGVPFL ETSAKTGMNV
ELAFLAIAKE LKYRAGHQAD EPSFQIRDYV ESQKKRSSCC SFM
