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RAB3_CAEEL
ID   RAB3_CAEEL              Reviewed;         219 AA.
AC   Q94986;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Ras-related protein Rab-3;
GN   Name=rab-3; ORFNames=C18A3.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Nonet M.L., Staunton J.E., Kilgard M.P., Fergestad T., Jorgensen E.,
RA   Hartweig E., Horvitz H.R., Meyer B.J.;
RT   "Functional synapses that are partially depleted of vesicles in C. elegans
RT   rab-3 mutants.";
RL   Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=14722103; DOI=10.1074/jbc.m306812200;
RA   Fukuda M., Kanno E., Yamamoto A.;
RT   "Rabphilin and Noc2 are recruited to dense-core vesicles through specific
RT   interaction with Rab27A in PC12 cells.";
RL   J. Biol. Chem. 279:13065-13075(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [4]
RP   FUNCTION, AND MUTAGENESIS OF THR-36 AND GLN-81.
RX   PubMed=21029864; DOI=10.1016/j.cell.2010.09.024;
RA   Bai J., Hu Z., Dittman J.S., Pym E.C., Kaplan J.M.;
RT   "Endophilin functions as a membrane-bending molecule and is delivered to
RT   endocytic zones by exocytosis.";
RL   Cell 143:430-441(2010).
RN   [5]
RP   FUNCTION, AND MUTAGENESIS OF 76-TRP--CYS-219.
RX   PubMed=27116976; DOI=10.1534/genetics.115.186064;
RA   Bhat J.M., Hutter H.;
RT   "Pioneer Axon Navigation Is Controlled by AEX-3, a Guanine Nucleotide
RT   Exchange Factor for RAB-3 in Caenorhabditis elegans.";
RL   Genetics 203:1235-1247(2016).
CC   -!- FUNCTION: Involved in exocytosis by regulating a late step in synaptic
CC       vesicle fusion. Could play a role in neurotransmitter release by
CC       regulating membrane flow in the nerve terminal (By similarity). Plays a
CC       role in the recruitment of endophilin unc-57 to synaptic vesicles
CC       (PubMed:21029864). Probably by controlling dense-core vesicle
CC       trafficking, plays a role in the AVG neuron-mediated formation of the
CC       right axon tract of the ventral nerve cord (PubMed:27116976).
CC       {ECO:0000250, ECO:0000269|PubMed:21029864,
CC       ECO:0000269|PubMed:27116976}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; U68265; AAB16980.1; -; mRNA.
DR   EMBL; U68266; AAB16981.1; -; mRNA.
DR   EMBL; AB112928; BAD07033.1; -; mRNA.
DR   EMBL; FO080599; CCD65021.1; -; Genomic_DNA.
DR   RefSeq; NP_001021974.1; NM_001026803.2.
DR   AlphaFoldDB; Q94986; -.
DR   SMR; Q94986; -.
DR   BioGRID; 39313; 1.
DR   STRING; 6239.C18A3.6a; -.
DR   EPD; Q94986; -.
DR   PaxDb; Q94986; -.
DR   EnsemblMetazoa; C18A3.6b.1; C18A3.6b.1; WBGene00004267.
DR   UCSC; C18A3.6a; c. elegans.
DR   WormBase; C18A3.6b; CE20518; WBGene00004267; rab-3.
DR   eggNOG; KOG0093; Eukaryota.
DR   HOGENOM; CLU_041217_10_1_1; -.
DR   InParanoid; Q94986; -.
DR   Reactome; R-CEL-181429; Serotonin Neurotransmitter Release Cycle.
DR   Reactome; R-CEL-181430; Norepinephrine Neurotransmitter Release Cycle.
DR   Reactome; R-CEL-210500; Glutamate Neurotransmitter Release Cycle.
DR   Reactome; R-CEL-212676; Dopamine Neurotransmitter Release Cycle.
DR   Reactome; R-CEL-264642; Acetylcholine Neurotransmitter Release Cycle.
DR   Reactome; R-CEL-6798695; Neutrophil degranulation.
DR   Reactome; R-CEL-8873719; RAB geranylgeranylation.
DR   Reactome; R-CEL-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   Reactome; R-CEL-888590; GABA synthesis, release, reuptake and degradation.
DR   PRO; PR:Q94986; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00004267; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   ExpressionAtlas; Q94986; baseline and differential.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0043005; C:neuron projection; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0008021; C:synaptic vesicle; IDA:WormBase.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; ISS:WormBase.
DR   GO; GO:0031489; F:myosin V binding; IBA:GO_Central.
DR   GO; GO:0006935; P:chemotaxis; IMP:WormBase.
DR   GO; GO:0007617; P:mating behavior; IMP:WormBase.
DR   GO; GO:1905488; P:positive regulation of anterior/posterior axon guidance; IMP:UniProtKB.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR   GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR   GO; GO:0017157; P:regulation of exocytosis; IBA:GO_Central.
DR   GO; GO:0040012; P:regulation of locomotion; IMP:WormBase.
DR   GO; GO:0043051; P:regulation of pharyngeal pumping; IMP:WormBase.
DR   GO; GO:0032228; P:regulation of synaptic transmission, GABAergic; IMP:UniProtKB.
DR   GO; GO:0007271; P:synaptic transmission, cholinergic; IMP:WormBase.
DR   GO; GO:0007419; P:ventral cord development; IMP:UniProtKB.
DR   GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR   CDD; cd01865; Rab3; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR037872; Rab3.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Exocytosis; GTP-binding; Lipoprotein; Membrane; Methylation;
KW   Nucleotide-binding; Prenylation; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..219
FT                   /note="Ras-related protein Rab-3"
FT                   /id="PRO_0000121091"
FT   REGION          191..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           51..59
FT                   /note="Effector region"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        200..219
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         29..37
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:O95716"
FT   BINDING         48..54
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P63012"
FT   BINDING         77..81
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62820"
FT   BINDING         135..138
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:O95716"
FT   BINDING         165..167
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:O95716"
FT   MOD_RES         219
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250"
FT   LIPID           217
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           219
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
FT   MUTAGEN         36
FT                   /note="T->N: Probably constitutively inactive (GDP-locked
FT                   form). Fails to prevent unc-57 enrichment to synaptic
FT                   vesicles in an unc-13 mutant background."
FT                   /evidence="ECO:0000269|PubMed:9851916"
FT   MUTAGEN         76..219
FT                   /note="Missing: In js49; abnormal cross-over of the AVG
FT                   neuron axon during the formation of the right axon tract of
FT                   the ventral nerve cord in 10 percent of mutants. In a nid-1
FT                   (cg119) mutant background, approximately 40 percent of
FT                   mutants have impaired AVG axon navigation."
FT                   /evidence="ECO:0000269|PubMed:27116976"
FT   MUTAGEN         81
FT                   /note="Q->L: Probably constitutively active (GTP-locked
FT                   form). Reduced unc-57 enrichment to synaptic vesicles in an
FT                   unc-13 mutant background."
FT                   /evidence="ECO:0000269|PubMed:9851916"
SQ   SEQUENCE   219 AA;  24760 MW;  7492444BCCC27C27 CRC64;
     MAAGGQPQGA TPGQPDQNFD YMFKLLIIGN SSVGKTSFLF RYCDDSFTSA FVSTVGIDFK
     VKTVFRGDKR VKLQIWDTAG QERYRTITTA YYRGAMGFIL MYDITNEESF NSVQDWCTQI
     KTYSWENAQV VLVGNKCDMD SERVVSMDRG RQLADQLGLE FFETSAKENI NVKAVFEKLV
     EIICDKMAES LDKDPQQQPK GQKLEANPTQ KPAQQQCNC
 
 
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