RAB42_HUMAN
ID RAB42_HUMAN Reviewed; 218 AA.
AC Q8N4Z0; A0A1W2PQ57; B2R5G2;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2017, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Ras-related protein Rab-42 {ECO:0000305};
GN Name=RAB42 {ECO:0000312|HGNC:HGNC:28702};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N4Z0-1; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-17857145, EBI-741158;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P62820}; Lipid-
CC anchor {ECO:0000250|UniProtKB:P62820}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N4Z0-2; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N4Z0-1; Sequence=VSP_059258;
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; AK312176; BAG35109.1; -; mRNA.
DR EMBL; AL513497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX07684.1; -; Genomic_DNA.
DR EMBL; BC033175; AAH33175.1; -; mRNA.
DR CCDS; CCDS325.1; -. [Q8N4Z0-1]
DR CCDS; CCDS85943.1; -. [Q8N4Z0-2]
DR RefSeq; NP_001180461.1; NM_001193532.1. [Q8N4Z0-2]
DR RefSeq; NP_689517.1; NM_152304.1. [Q8N4Z0-1]
DR AlphaFoldDB; Q8N4Z0; -.
DR SMR; Q8N4Z0; -.
DR BioGRID; 125422; 4.
DR IntAct; Q8N4Z0; 1.
DR STRING; 9606.ENSP00000362932; -.
DR iPTMnet; Q8N4Z0; -.
DR PhosphoSitePlus; Q8N4Z0; -.
DR BioMuta; RAB42; -.
DR DMDM; 74751010; -.
DR jPOST; Q8N4Z0; -.
DR MassIVE; Q8N4Z0; -.
DR MaxQB; Q8N4Z0; -.
DR PaxDb; Q8N4Z0; -.
DR PeptideAtlas; Q8N4Z0; -.
DR PRIDE; Q8N4Z0; -.
DR ProteomicsDB; 71993; -.
DR Antibodypedia; 30977; 66 antibodies from 16 providers.
DR DNASU; 115273; -.
DR Ensembl; ENST00000373826.3; ENSP00000362932.3; ENSG00000188060.8. [Q8N4Z0-1]
DR Ensembl; ENST00000465518.3; ENSP00000491546.1; ENSG00000188060.8. [Q8N4Z0-2]
DR GeneID; 115273; -.
DR KEGG; hsa:115273; -.
DR MANE-Select; ENST00000465518.3; ENSP00000491546.1; NM_001193532.3; NP_001180461.1.
DR UCSC; uc001bqu.4; human. [Q8N4Z0-2]
DR CTD; 115273; -.
DR DisGeNET; 115273; -.
DR GeneCards; RAB42; -.
DR HGNC; HGNC:28702; RAB42.
DR HPA; ENSG00000188060; Tissue enriched (lymphoid).
DR neXtProt; NX_Q8N4Z0; -.
DR OpenTargets; ENSG00000188060; -.
DR PharmGKB; PA134976516; -.
DR VEuPathDB; HostDB:ENSG00000188060; -.
DR eggNOG; KOG0091; Eukaryota.
DR GeneTree; ENSGT00940000162094; -.
DR HOGENOM; CLU_041217_23_3_1; -.
DR InParanoid; Q8N4Z0; -.
DR OMA; CSYQFRI; -.
DR OrthoDB; 1416096at2759; -.
DR PhylomeDB; Q8N4Z0; -.
DR PathwayCommons; Q8N4Z0; -.
DR Reactome; R-HSA-8873719; RAB geranylgeranylation.
DR SignaLink; Q8N4Z0; -.
DR BioGRID-ORCS; 115273; 9 hits in 1037 CRISPR screens.
DR ChiTaRS; RAB42; human.
DR GenomeRNAi; 115273; -.
DR Pharos; Q8N4Z0; Tdark.
DR PRO; PR:Q8N4Z0; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8N4Z0; protein.
DR Bgee; ENSG00000188060; Expressed in lymph node and 96 other tissues.
DR Genevisible; Q8N4Z0; HS.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0019003; F:GDP binding; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; GTP-binding; Lipoprotein; Membrane;
KW Nucleotide-binding; Prenylation; Reference proteome.
FT CHAIN 1..218
FT /note="Ras-related protein Rab-42"
FT /id="PRO_0000269848"
FT BINDING 16..24
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT BINDING 40..46
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT BINDING 70..74
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT BINDING 129..132
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT BINDING 159..161
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT LIPID 216
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT LIPID 218
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT VAR_SEQ 1..113
FT /note="Missing (in isoform 2)"
FT /id="VSP_059258"
SQ SEQUENCE 218 AA; 24133 MW; B06EB7CC11591611 CRC64;
MEAEGCRYQF RVALLGDAAV GKTSLLRSYV AGAPGAPEPE PEPEPTVGAE CYRRALQLRA
GPRVKLQLWD TAGHERFRCI TRSFYRNVVG VLLVFDVTNR KSFEHIQDWH QEVMATQGPD
KVIFLLVGHK SDLQSTRCVS AQEAEELAAS LGMAFVETSV KNNCNVDLAF DTLADAIQQA
LQQGDIKLEE GWGGVRLIHK TQIPRSPSRK QHSGPCQC
