RAB42_MOUSE
ID RAB42_MOUSE Reviewed; 215 AA.
AC Q0PD08;
DT 20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Ras-related protein Rab-42 {ECO:0000305};
GN Name=Rab42 {ECO:0000312|MGI:MGI:2441753};
GN Synonyms=Rab43 {ECO:0000303|PubMed:16923123};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=16923123; DOI=10.1111/j.1365-2443.2006.00997.x;
RA Itoh T., Satoh M., Kanno E., Fukuda M.;
RT "Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing
RT proteins based on their Rab-binding activity.";
RL Genes Cells 11:1023-1037(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P62820}; Lipid-
CC anchor {ECO:0000250|UniProtKB:P62820}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; AB232642; BAF02904.1; -; mRNA.
DR EMBL; AL670276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC132060; AAI32061.1; -; mRNA.
DR EMBL; BC132062; AAI32063.1; -; mRNA.
DR CCDS; CCDS38898.1; -.
DR RefSeq; NP_001075120.1; NM_001081651.1.
DR AlphaFoldDB; Q0PD08; -.
DR SMR; Q0PD08; -.
DR STRING; 10090.ENSMUSP00000047735; -.
DR PhosphoSitePlus; Q0PD08; -.
DR PaxDb; Q0PD08; -.
DR PeptideAtlas; Q0PD08; -.
DR PRIDE; Q0PD08; -.
DR ProteomicsDB; 255066; -.
DR Antibodypedia; 30977; 66 antibodies from 16 providers.
DR Ensembl; ENSMUST00000040411; ENSMUSP00000047735; ENSMUSG00000089687.
DR GeneID; 242681; -.
DR KEGG; mmu:242681; -.
DR UCSC; uc008vay.1; mouse.
DR CTD; 115273; -.
DR MGI; MGI:2441753; Rab42.
DR VEuPathDB; HostDB:ENSMUSG00000089687; -.
DR eggNOG; KOG0091; Eukaryota.
DR GeneTree; ENSGT00940000162094; -.
DR HOGENOM; CLU_041217_23_1_1; -.
DR InParanoid; Q0PD08; -.
DR OMA; CSYQFRI; -.
DR OrthoDB; 1416096at2759; -.
DR PhylomeDB; Q0PD08; -.
DR TreeFam; TF300032; -.
DR BioGRID-ORCS; 242681; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Rab43; mouse.
DR PRO; PR:Q0PD08; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q0PD08; protein.
DR Bgee; ENSMUSG00000089687; Expressed in spermatocyte and 54 other tissues.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
PE 2: Evidence at transcript level;
KW GTP-binding; Lipoprotein; Membrane; Nucleotide-binding; Prenylation;
KW Reference proteome.
FT CHAIN 1..215
FT /note="Ras-related protein Rab-42"
FT /id="PRO_0000442580"
FT REGION 196..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 16..24
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT BINDING 40..44
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT BINDING 68..72
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT BINDING 127..130
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT BINDING 156..158
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT LIPID 213
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT LIPID 215
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:P62820"
SQ SEQUENCE 215 AA; 23568 MW; 939D2FA0A251710A CRC64;
MEAAGCSYQF RIALLGDAGV GKTSLLRCYV AGARGAAEPD PEPTVGVEFY SRALQLPAGL
RVKLQLWDTA GQECFRCITR SFYRNMVGVL LVFDVTNRES FEHIQAWHQE VVSTQGPDKV
VFLLVGHKCD LNTRCVSSQE AEELAASLGM GFMETSAKSN CNVDLAFDTV TSAIEQALQQ
GDIKLDKDWA GVRLLHRSPN PRSSSRKQDS GTCQC
