ID   RAB5B_DICDI             Reviewed;         214 AA.
AC   Q54RX9;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Putative ras-related protein Rab-5B;
GN   Name=rab5B; ORFNames=DDB_G0282847;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- PTM: This sequence lacks the C-terminal cysteine motifs subject to
CC       isoprenylation in other Rab proteins.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AAFI02000047; EAL66003.1; -; Genomic_DNA.
DR   RefSeq; XP_639358.1; XM_634266.1.
DR   AlphaFoldDB; Q54RX9; -.
DR   SMR; Q54RX9; -.
DR   STRING; 44689.DDB0229394; -.
DR   PaxDb; Q54RX9; -.
DR   EnsemblProtists; EAL66003; EAL66003; DDB_G0282847.
DR   GeneID; 8623798; -.
DR   KEGG; ddi:DDB_G0282847; -.
DR   dictyBase; DDB_G0282847; rab5B.
DR   eggNOG; KOG0092; Eukaryota.
DR   HOGENOM; CLU_041217_10_2_1; -.
DR   InParanoid; Q54RX9; -.
DR   OMA; SESHRTC; -.
DR   PhylomeDB; Q54RX9; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005811; C:lipid droplet; HDA:dictyBase.
DR   GO; GO:0140220; C:pathogen-containing vacuole; HDA:dictyBase.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   5: Uncertain;
KW   GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..214
FT                   /note="Putative ras-related protein Rab-5B"
FT                   /id="PRO_0000330645"
FT   MOTIF           77..85
FT                   /note="Effector region"
FT                   /evidence="ECO:0000255"
FT   BINDING         56..63
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         103..107
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         161..164
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   214 AA;  23483 MW;  28E2B6D8679CDA90 CRC64;
     MSNANNNGQA TAKGGCCGGG GSQDNKANQN SGIVVSNTST DNRNKFDKGF KLVLLGEMNT
     GKTCISSRLV RNEFGPTDST IGAAFLVKSM VVDNINIKLE IWDTAGQERY RSLTPMYYRG
     AAAAVVVYDI TKKNTFETLK RWVSELQKHA SPNLILALAG NKVDLPNREV QVDEVNRYIS
     ELGNAIFFET SAASGQNINE LFTEICRRLI ENYK