RAB5C_CHICK
ID RAB5C_CHICK Reviewed; 216 AA.
AC Q98932;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Ras-related protein Rab-5C;
DE EC=3.6.5.2 {ECO:0000250|UniProtKB:P20339};
DE AltName: Full=Rab5C-like protein;
GN Name=RAB5C;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC TISSUE=Liver;
RX PubMed=9602038; DOI=10.1016/s0167-4781(98)00053-0;
RA Bojer C.D.A., Wohlrab F., Ivessa N.E.;
RT "Molecular cloning and expression of an avian rab5 homolog.";
RL Biochim. Biophys. Acta 1398:25-31(1998).
CC -!- FUNCTION: Protein transport. Probably involved in vesicular traffic.
CC {ECO:0000250|UniProtKB:P20339}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC Evidence={ECO:0000250|UniProtKB:P20339};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000250|UniProtKB:P20339};
CC -!- ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors
CC (GEFs) which promote the exchange of bound GDP for free GTP.
CC {ECO:0000250|UniProtKB:P18066}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P20339};
CC Lipid-anchor {ECO:0000250|UniProtKB:P20339}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:P20339}. Early endosome membrane
CC {ECO:0000250|UniProtKB:P20339}; Lipid-anchor
CC {ECO:0000250|UniProtKB:P20339}.
CC -!- TISSUE SPECIFICITY: Detected in brain, ovary, rectum, small intestine,
CC large intestine, liver, spleen, follicle and kidney (at protein level).
CC {ECO:0000269|PubMed:9602038}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; Y07811; CAA69142.1; -; mRNA.
DR RefSeq; NP_989856.1; NM_204525.1.
DR RefSeq; XP_015155054.1; XM_015299568.1.
DR AlphaFoldDB; Q98932; -.
DR SMR; Q98932; -.
DR STRING; 9031.ENSGALP00000005302; -.
DR PaxDb; Q98932; -.
DR Ensembl; ENSGALT00000005312; ENSGALP00000005302; ENSGALG00000003359.
DR Ensembl; ENSGALT00000061358; ENSGALP00000044276; ENSGALG00000003359.
DR Ensembl; ENSGALT00000078413; ENSGALP00000045206; ENSGALG00000003359.
DR GeneID; 395197; -.
DR KEGG; gga:395197; -.
DR CTD; 5878; -.
DR VEuPathDB; HostDB:geneid_395197; -.
DR eggNOG; KOG0092; Eukaryota.
DR GeneTree; ENSGT00940000154971; -.
DR HOGENOM; CLU_041217_10_2_1; -.
DR InParanoid; Q98932; -.
DR OMA; TYAEEES; -.
DR OrthoDB; 1340129at2759; -.
DR PhylomeDB; Q98932; -.
DR Reactome; R-GGA-432722; Golgi Associated Vesicle Biogenesis.
DR Reactome; R-GGA-6798695; Neutrophil degranulation.
DR Reactome; R-GGA-8854214; TBC/RABGAPs.
DR Reactome; R-GGA-8856828; Clathrin-mediated endocytosis.
DR Reactome; R-GGA-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR PRO; PR:Q98932; -.
DR Proteomes; UP000000539; Chromosome 27.
DR Bgee; ENSGALG00000003359; Expressed in lung and 13 other tissues.
DR ExpressionAtlas; Q98932; baseline and differential.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030139; C:endocytic vesicle; IBA:GO_Central.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR GO; GO:0019003; F:GDP binding; ISS:UniProtKB.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0048227; P:plasma membrane to endosome transport; IEA:Ensembl.
DR GO; GO:0030100; P:regulation of endocytosis; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Endosome; GTP-binding; Hydrolase; Lipoprotein; Membrane;
KW Nucleotide-binding; Prenylation; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..216
FT /note="Ras-related protein Rab-5C"
FT /id="PRO_0000276769"
FT REGION 184..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 50..58
FT /note="Effector region"
FT /evidence="ECO:0000255"
FT COMPBIAS 200..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 28..36
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P20339"
FT BINDING 47..53
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P20339"
FT BINDING 76..80
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P20339"
FT BINDING 134..137
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P20339"
FT BINDING 164..166
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P20339"
FT LIPID 213
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:P20339"
FT LIPID 214
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:P20339"
SQ SEQUENCE 216 AA; 23554 MW; 4EF604EE314FE6C7 CRC64;
MAGRGGAARP NGPAAGNKIC QFKLVLLGES AVGKSSLVLR FVKGQFHEYQ ESTIGAAFLT
QTVCLDDTTV KFEIWDTAGQ ERYHSLAPMY YRGAQAAIVV YDITNTDTFV RAKNWVKELQ
RQASPNIVIA LAGNKADLAT KRAVDFQDAQ TYADDNSLLF METSAKTAMN VNEIFMAIAK
KLPKNEPQNA PGGPGRNRVV DLQESSQPSR SQCCSN
