RAB5_TOBAC
ID RAB5_TOBAC Reviewed; 200 AA.
AC P29687;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Ras-related protein Rab5;
GN Name=RAB5;
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. SR1; TISSUE=Leaf;
RX PubMed=1643285; DOI=10.1007/bf00027080;
RA Dallmann G., Sticher L., Marshallsay C., Nagy F.;
RT "Molecular characterization of tobacco cDNAs encoding two small GTP-binding
RT proteins.";
RL Plant Mol. Biol. 19:847-857(1992).
CC -!- FUNCTION: Protein transport. Probably involved in vesicular traffic (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Virtually not expressed in leaves, higher in stems
CC and roots, and highest in flowers.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; X63875; CAA45352.1; -; mRNA.
DR PIR; S23524; S23524.
DR AlphaFoldDB; P29687; -.
DR SMR; P29687; -.
DR STRING; 4097.P29687; -.
DR PRIDE; P29687; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0030139; C:endocytic vesicle; IBA:GO_Central.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding;
KW Prenylation; Protein transport; Reference proteome; Transport.
FT CHAIN 1..200
FT /note="Ras-related protein Rab5"
FT /id="PRO_0000121278"
FT MOTIF 39..47
FT /note="Effector region"
FT /evidence="ECO:0000255"
FT BINDING 17..25
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P20339"
FT BINDING 36..42
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P20339"
FT BINDING 65..69
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P20339"
FT BINDING 123..126
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P20339"
FT BINDING 153..155
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P20339"
FT LIPID 198
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 199
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 200 AA; 21950 MW; 46643D008C5C7BB6 CRC64;
MASRRHNNLN AKLVLLGDMG AGKSSLVIRF VKGQFLEFQE STIGAAFFSS TVSVNNATVK
FEIWDTAGQE RYHSLAPMYY RGAAAAIIVY DITSTESLAR AKKWVQELQK QGNPNMVMAL
AGNKADLEDK RKVTAEEARL YAEENGLFFM ETSAKTATNV NDIFYEIAKR LPRAQPAQNP
AGMVLEDKPA QGSQAASCCT
