ID   RAB6A_CHICK             Reviewed;         208 AA.
AC   Q1KME6;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Ras-related protein Rab-6A;
GN   Name=RAB6A;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Adipose tissue;
RA   Dong B., Meng H., Gu Z.L., Gong D.Q.;
RT   "Cloning and sequence analysis of the chicken RAB6 gene.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protein transport. Regulator of membrane traffic from the
CC       Golgi apparatus towards the endoplasmic reticulum (ER). Involved in
CC       COPI-independent retrograde transport from the Golgi to the ER.
CC       {ECO:0000250|UniProtKB:P20340}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:P20340}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:P20340}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; DQ470138; ABF00126.1; -; mRNA.
DR   RefSeq; NP_001038105.1; NM_001044640.1.
DR   AlphaFoldDB; Q1KME6; -.
DR   SMR; Q1KME6; -.
DR   STRING; 9031.ENSGALP00000030639; -.
DR   Ensembl; ENSGALT00000031276; ENSGALP00000030639; ENSGALG00000017320.
DR   GeneID; 419063; -.
DR   KEGG; gga:419063; -.
DR   CTD; 5870; -.
DR   VEuPathDB; HostDB:geneid_419063; -.
DR   eggNOG; KOG0094; Eukaryota.
DR   GeneTree; ENSGT00940000154769; -.
DR   HOGENOM; CLU_041217_10_2_1; -.
DR   InParanoid; Q1KME6; -.
DR   OMA; PVSNDGC; -.
DR   OrthoDB; 1277051at2759; -.
DR   PhylomeDB; Q1KME6; -.
DR   Reactome; R-GGA-6798695; Neutrophil degranulation.
DR   Reactome; R-GGA-6811436; COPI-independent Golgi-to-ER retrograde traffic.
DR   Reactome; R-GGA-6811438; Intra-Golgi traffic.
DR   Reactome; R-GGA-6811440; Retrograde transport at the Trans-Golgi-Network.
DR   Reactome; R-GGA-8854214; TBC/RABGAPs.
DR   Reactome; R-GGA-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   PRO; PR:Q1KME6; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000017320; Expressed in brain and 13 other tissues.
DR   ExpressionAtlas; Q1KME6; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0034067; P:protein localization to Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein;
KW   Membrane; Methylation; Nucleotide-binding; Prenylation; Protein transport;
KW   Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..208
FT                   /note="Ras-related protein Rab-6A"
FT                   /id="PRO_0000260745"
FT   MOTIF           42..50
FT                   /note="Effector region"
FT                   /evidence="ECO:0000250"
FT   BINDING         20..27
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         45
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         68..72
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         126..129
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         208
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250"
FT   LIPID           206
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           208
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   208 AA;  23491 MW;  CBF8DD283D0A5931 CRC64;
     MSAGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF LSKTMYLEDR
     TIRLQLWDTA GQERFRSLIP SYIRDSAAAV VVYDITNVNS FQQTTKWIDD VRTERGSDVI
     IMLVGNKTDL ADKRQVSIEE GERKAKELNV MFIETSAKAG YNVKQLFRRV AAALPGMEST
     QDKSREDMID IKLEKPQEQP VSEGGCSC