ID   RAB6A_PONAB             Reviewed;         208 AA.
AC   Q5RAV6;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Ras-related protein Rab-6A;
GN   Name=RAB6A;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protein transport. Regulator of membrane traffic from the
CC       Golgi apparatus towards the endoplasmic reticulum (ER). Involved in
CC       COPI-independent retrograde transport from the Golgi to the ER (By
CC       similarity). {ECO:0000250|UniProtKB:P20340}.
CC   -!- SUBUNIT: Interacts with BICDL1; leads to its accumulation in the
CC       pericentrosomal region. Interacts with SCYL1BP1. Interacts with VSP52
CC       and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with
CC       RAB6IP1 (via its RUN 1 domain). Interacts with RAB6KIFL. Interacts with
CC       BICD1. Interacts with BICD2. Interacts with TMF1. Interacts (GTP-bound)
CC       with DYNLRB1; the interaction is direct (By similarity). Interacts with
CC       PIFO (By similarity). Interacts (GTP-bound) with APBA1/MINT1 (By
CC       similarity). Interacts with RIC1 and RGP1; the interactions are direct
CC       with a preference for RAB6A-GDP. {ECO:0000250|UniProtKB:P20340,
CC       ECO:0000250|UniProtKB:P35279}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:P20340}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:P20340}. Note=BICD2 facilitates its targeting to
CC       Golgi apparatus membrane.
CC   -!- PTM: Prenylated. {ECO:0000250|UniProtKB:P20340}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR858905; CAH91104.1; -; mRNA.
DR   RefSeq; NP_001125644.1; NM_001132172.1.
DR   AlphaFoldDB; Q5RAV6; -.
DR   SMR; Q5RAV6; -.
DR   STRING; 9601.ENSPPYP00000004186; -.
DR   PRIDE; Q5RAV6; -.
DR   Ensembl; ENSPPYT00000004357; ENSPPYP00000004186; ENSPPYG00000003663.
DR   GeneID; 100172563; -.
DR   KEGG; pon:100172563; -.
DR   CTD; 5870; -.
DR   eggNOG; KOG0094; Eukaryota.
DR   GeneTree; ENSGT00940000154769; -.
DR   HOGENOM; CLU_041217_10_2_1; -.
DR   InParanoid; Q5RAV6; -.
DR   OMA; PVSNDGC; -.
DR   OrthoDB; 1277051at2759; -.
DR   TreeFam; TF300803; -.
DR   Proteomes; UP000001595; Chromosome 11.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
DR   GO; GO:0003924; F:GTPase activity; ISS:UniProtKB.
DR   GO; GO:0034067; P:protein localization to Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein;
KW   Membrane; Methylation; Nucleotide-binding; Phosphoprotein; Prenylation;
KW   Protein transport; Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P20340"
FT   CHAIN           2..208
FT                   /note="Ras-related protein Rab-6A"
FT                   /id="PRO_0000243920"
FT   MOTIF           42..50
FT                   /note="Effector region"
FT                   /evidence="ECO:0000250"
FT   BINDING         20..28
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         68..72
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         126..129
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         156..158
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:P20340"
FT   MOD_RES         184
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P35279"
FT   MOD_RES         208
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250"
FT   LIPID           206
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           208
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   208 AA;  23593 MW;  C9A3C2DDBF6C3E9E CRC64;
     MSTGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF LSKTMYLEDR
     TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNVNS FQQTTKWIDD VRTERGSDVI
     IMLVGNKTDL ADKRQVSIEE GERKAKELNV MFIETSAKAG YNVKQLFRRV AAALPGMEST
     QDRSREDMID IKLEKPQEQP VSEGGCSC