RAB6D_HUMAN
ID RAB6D_HUMAN Reviewed; 254 AA.
AC Q53S08;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Ras-related protein Rab-6D {ECO:0000305};
DE AltName: Full=Rab6-like protein WTH3DI {ECO:0000305};
GN Name=RAB6D {ECO:0000312|HGNC:HGNC:30272};
GN Synonyms=WTH3DI {ECO:0000312|EMBL:AAY33873.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16923123; DOI=10.1111/j.1365-2443.2006.00997.x;
RA Itoh T., Satoh M., Kanno E., Fukuda M.;
RT "Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing
RT proteins based on their Rab-binding activity.";
RL Genes Cells 11:1023-1037(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Tian K., Jurukovski V., Xu H.;
RT "WTH3DI, a homolog of the WTH3 gene.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; AB232598; BAF02860.1; -; mRNA.
DR EMBL; AY970296; AAY33873.1; -; Genomic_DNA.
DR EMBL; AC073869; AAX93251.1; -; Genomic_DNA.
DR CCDS; CCDS82514.1; -.
DR RefSeq; NP_001071105.1; NM_001077637.1.
DR AlphaFoldDB; Q53S08; -.
DR SMR; Q53S08; -.
DR IntAct; Q53S08; 1.
DR iPTMnet; Q53S08; -.
DR PhosphoSitePlus; Q53S08; -.
DR BioMuta; ENSG00000233087; -.
DR jPOST; Q53S08; -.
DR MassIVE; Q53S08; -.
DR MaxQB; Q53S08; -.
DR PeptideAtlas; Q53S08; -.
DR PRIDE; Q53S08; -.
DR Antibodypedia; 78324; 2 antibodies from 2 providers.
DR DNASU; 150786; -.
DR Ensembl; ENST00000623617.3; ENSP00000490038.1; ENSG00000233087.8.
DR GeneID; 150786; -.
DR KEGG; hsa:150786; -.
DR MANE-Select; ENST00000623617.3; ENSP00000490038.1; NM_001077637.3; NP_001071105.1.
DR CTD; 150786; -.
DR GeneCards; RAB6D; -.
DR HGNC; HGNC:30272; RAB6D.
DR HPA; ENSG00000233087; Tissue enriched (parathyroid).
DR neXtProt; NX_Q53S08; -.
DR VEuPathDB; HostDB:ENSG00000233087; -.
DR GeneTree; ENSGT00940000168192; -.
DR OMA; RFIETRA; -.
DR OrthoDB; 1277051at2759; -.
DR PathwayCommons; Q53S08; -.
DR BioGRID-ORCS; 150786; 6 hits in 188 CRISPR screens.
DR ChiTaRS; WTH3DI; human.
DR GenomeRNAi; 150786; -.
DR Pharos; Q53S08; Tdark.
DR PRO; PR:Q53S08; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q53S08; protein.
DR Bgee; ENSG00000233087; Expressed in superior frontal gyrus and 50 other tissues.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..254
FT /note="Ras-related protein Rab-6D"
FT /id="PRO_0000443825"
FT BINDING 20..28
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT BINDING 38..45
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT BINDING 68..72
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT BINDING 126..129
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT BINDING 156..158
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
SQ SEQUENCE 254 AA; 28242 MW; 0FA8F665DFDAA081 CRC64;
MSAGGDFGNP LRKFKLVFLG EQSVAKTSLI TRFRYDSFDN TYQAIIGIDF LSKTMYLEDG
TIGLRLWDTA GQERLRSLIP RYIRDSAAAV VVYDITNVNS FQQTTKWIDD VRTEGGSDVI
ITLVGNKTDL ADKRQVSIEE GERKAKGLNV TFIETRAKAG YNVKQLFRRV AAALPGMEST
QDGSREDMSD IKLEKPQEQT VSEGGCSCYS PMSSSTLPQK PPYSFIDCSV NIGLNLFPSL
ITFCNSSLLP VSWR
