RAB7B_BOVIN
ID RAB7B_BOVIN Reviewed; 200 AA.
AC Q08DE8;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Ras-related protein Rab-7b;
GN Name=RAB7B;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal skin;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Controls vesicular trafficking from endosomes to the trans-
CC Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and
CC can suppress TLR9-triggered TNFA, IL6, and IFNB production in
CC macrophages by promoting TLR9 lysosomal degradation. Also negatively
CC regulates TLR4 signaling in macrophages by promoting lysosomal
CC degradation of TLR4. Promotes megakaryocytic differentiation by
CC increasing NF-kappa-B-dependent IL6 production and subsequently
CC enhancing the association of STAT3 with GATA1. Not involved in the
CC regulation of the EGF- and EGFR degradation pathway (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Late endosome {ECO:0000250|UniProtKB:Q96AH8}.
CC Lysosome {ECO:0000250|UniProtKB:Q96AH8}. Golgi apparatus
CC {ECO:0000250|UniProtKB:Q96AH8}. Golgi apparatus, trans-Golgi network
CC {ECO:0000250|UniProtKB:Q96AH8}. Cytoplasmic vesicle, phagosome
CC {ECO:0000250|UniProtKB:Q96AH8}. Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side
CC {ECO:0000305}. Note=Recruited to phagosomes containing S.aureus or
CC M.tuberculosis. {ECO:0000250|UniProtKB:Q96AH8}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; BC123789; AAI23790.1; -; mRNA.
DR RefSeq; NP_001071481.1; NM_001078013.1.
DR RefSeq; XP_005216746.1; XM_005216689.3.
DR AlphaFoldDB; Q08DE8; -.
DR SMR; Q08DE8; -.
DR STRING; 9913.ENSBTAP00000016976; -.
DR PaxDb; Q08DE8; -.
DR PRIDE; Q08DE8; -.
DR Ensembl; ENSBTAT00000016976; ENSBTAP00000016976; ENSBTAG00000012774.
DR GeneID; 538050; -.
DR KEGG; bta:538050; -.
DR CTD; 338382; -.
DR VEuPathDB; HostDB:ENSBTAG00000012774; -.
DR VGNC; VGNC:33661; RAB7B.
DR eggNOG; KOG0394; Eukaryota.
DR GeneTree; ENSGT00940000161943; -.
DR HOGENOM; CLU_041217_10_6_1; -.
DR InParanoid; Q08DE8; -.
DR OMA; ASSWCKE; -.
DR OrthoDB; 1172019at2759; -.
DR TreeFam; TF326442; -.
DR Reactome; R-BTA-8854214; TBC/RABGAPs.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000012774; Expressed in bone marrow and 102 other tissues.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0005770; C:late endosome; ISS:UniProtKB.
DR GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR GO; GO:0045335; C:phagocytic vesicle; ISS:UniProtKB.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IEA:Ensembl.
DR GO; GO:0008333; P:endosome to lysosome transport; IBA:GO_Central.
DR GO; GO:0034499; P:late endosome to Golgi transport; ISS:UniProtKB.
DR GO; GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; ISS:UniProtKB.
DR GO; GO:0034164; P:negative regulation of toll-like receptor 9 signaling pathway; ISS:UniProtKB.
DR GO; GO:0090385; P:phagosome-lysosome fusion; IBA:GO_Central.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; ISS:UniProtKB.
DR GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; ISS:UniProtKB.
DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle; Endosome; Golgi apparatus; GTP-binding; Lipoprotein;
KW Lysosome; Membrane; Nucleotide-binding; Phosphoprotein; Prenylation;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..200
FT /note="Ras-related protein Rab-7b"
FT /id="PRO_0000312560"
FT MOTIF 37..45
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 15..22
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 34..40
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 63..67
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 124..127
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 154..155
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 186
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8VEA8"
FT LIPID 199
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 200
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 200 AA; 22751 MW; AF381391E942BE2D CRC64;
MNPRKKVDLK LIIIGALGVG KTSLLHRYVH KTFYEDYQTT LGASILSKII ILEDTTLKLQ
IWDTGGQERF RSMVSTFYKG SDGCVLAFDV TDLESFEALE TWRGDVLAKT IPMEQPYPMV
VLGNKIDLED RQVPQEVAQG WCKEKDIPYF EVSAKNDINV VQAFEMLASR ALSRYRSILE
SYLTDSIKLS PEDQPKSRCC
