RAB8_DIPOM
ID RAB8_DIPOM Reviewed; 210 AA.
AC P22128;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1991, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Ras-related protein Rab-8;
DE AltName: Full=ORA2;
DE Flags: Precursor;
OS Diplobatis ommata (Ocellated electric ray) (Discopyge ommata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Batoidea; Torpediniformes; Narcinidae; Diplobatis.
OX NCBI_TaxID=1870830;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Electric lobe;
RX PubMed=1899244; DOI=10.1016/s0021-9258(18)52297-3;
RA Ngsee J.K., Elferink L.A., Scheller R.H.;
RT "A family of ras-like GTP-binding proteins expressed in electromotor
RT neurons.";
RL J. Biol. Chem. 266:2675-2680(1991).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M38391; AAA49232.1; -; mRNA.
DR PIR; B38625; B38625.
DR AlphaFoldDB; P22128; -.
DR SMR; P22128; -.
DR PRIDE; P22128; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation;
KW Nucleotide-binding; Prenylation.
FT CHAIN 1..207
FT /note="Ras-related protein Rab-8"
FT /id="PRO_0000121137"
FT PROPEP 208..210
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000370804"
FT MOTIF 37..45
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 15..22
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 63..67
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 121..124
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 207
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000255"
FT LIPID 207
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 210 AA; 24164 MW; 0F73EDB0DB8B9EEA CRC64;
MAKTYDYLFK LLLIGDSGVG KTCLLFRFSE DAFNTTFIST IGIDFKIRTV ELDGKKIKLQ
IWDTAGQERF RTITTAYYRG AMGIMKVYDI TNEKSFDNIK NWIRNIEEHA SSDVERMILG
NKCDMNEKRQ VSKERGEKLA IDYGIKFLET SAKSSINVEE AFITLARDIM TKLNKKMNEN
SLQEAVDKLK SPPKKPSQKK KQLSFRCSLL