RABA_DICDI
ID RABA_DICDI Reviewed; 201 AA.
AC P34141; Q54EN0;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Ras-related protein RabA;
DE Flags: Precursor;
GN Name=rabA; ORFNames=DDB_G0291233;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 3-201.
RC STRAIN=AX3;
RX PubMed=8294041; DOI=10.1016/0378-1119(93)90447-b;
RA Bush J.M. IV, Franek K., Daniel J.M., Spiegelman G.B., Weeks G.,
RA Cardelli J.A.;
RT "Cloning and characterization of five novel Dictyostelium discoideum rab-
RT related genes.";
RL Gene 136:55-60(1993).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000177; EAL61600.2; -; Genomic_DNA.
DR EMBL; L21011; AAC37382.1; -; mRNA.
DR RefSeq; XP_635210.2; XM_630118.2.
DR AlphaFoldDB; P34141; -.
DR SMR; P34141; -.
DR STRING; 44689.DDB0201658; -.
DR PaxDb; P34141; -.
DR PRIDE; P34141; -.
DR EnsemblProtists; EAL61600; EAL61600; DDB_G0291233.
DR GeneID; 8628156; -.
DR KEGG; ddi:DDB_G0291233; -.
DR dictyBase; DDB_G0291233; rabA.
DR eggNOG; KOG0084; Eukaryota.
DR HOGENOM; CLU_041217_23_1_1; -.
DR InParanoid; P34141; -.
DR OMA; NVERWFK; -.
DR PhylomeDB; P34141; -.
DR Reactome; R-DDI-162658; Golgi Cisternae Pericentriolar Stack Reorganization.
DR Reactome; R-DDI-204005; COPII-mediated vesicle transport.
DR Reactome; R-DDI-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DDI-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR Reactome; R-DDI-6811440; Retrograde transport at the Trans-Golgi-Network.
DR Reactome; R-DDI-8873719; RAB geranylgeranylation.
DR Reactome; R-DDI-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR PRO; PR:P34141; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation;
KW Nucleotide-binding; Prenylation; Reference proteome.
FT CHAIN 1..198
FT /note="Ras-related protein RabA"
FT /id="PRO_0000121268"
FT PROPEP 199..201
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000370831"
FT MOTIF 37..45
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 15..22
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 63..67
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 121..124
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 198
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000255"
FT LIPID 198
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT CONFLICT 4
FT /note="K -> E (in Ref. 2; AAC37382)"
FT /evidence="ECO:0000305"
FT CONFLICT 112
FT /note="D -> H (in Ref. 2; AAC37382)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 201 AA; 23016 MW; 21F35BF03FCCC40B CRC64;
MSKKYEHLFK FIFVGDSGVG KSSILLRFTE DTFTESYIST IGVDFKIKTV YIEGKAIKLQ
IWDTAGQERF RVHNNSQYRG CHAVMVVYDV TDQRSFENVA KWIQEIERYA RDNVIKMIIG
NKSDMISQKV VDPFLAQEFA DSLDITFKET SAKQAINIED AFISLVKLCI DRIEEFKPSS
TSSSTIILKK PQSQKSNCII N
