ID   RABEK_RAT               Reviewed;         372 AA.
AC   Q4V8F4;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Rab9 effector protein with kelch motifs;
GN   Name=Rabepk;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Rab9 effector required for endosome to trans-Golgi network
CC       (TGN) transport. {ECO:0000250|UniProtKB:Q7Z6M1}.
CC   -!- SUBUNIT: Interacts with PIKFYVE; the interaction recruits RABEPK to the
CC       endosomal membrane. Interacts with RAB9 in its GTP-bound conformation.
CC       {ECO:0000250|UniProtKB:Q7Z6M1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7Z6M1}.
CC       Endosome membrane {ECO:0000250|UniProtKB:Q7Z6M1}. Note=Interaction with
CC       PIKFYVE and subsequent phosphorylation recruits it to the endosomal
CC       membrane. {ECO:0000250|UniProtKB:Q7Z6M1}.
CC   -!- PTM: Phosphorylated on Ser residues by PIKFYVE.
CC       {ECO:0000250|UniProtKB:Q7Z6M1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC097415; AAH97415.1; -; mRNA.
DR   RefSeq; NP_001020042.2; NM_001024871.1.
DR   RefSeq; XP_006234017.1; XM_006233955.1.
DR   RefSeq; XP_006234019.1; XM_006233957.3.
DR   RefSeq; XP_006234020.1; XM_006233958.1.
DR   AlphaFoldDB; Q4V8F4; -.
DR   SMR; Q4V8F4; -.
DR   STRING; 10116.ENSRNOP00000025194; -.
DR   PhosphoSitePlus; Q4V8F4; -.
DR   jPOST; Q4V8F4; -.
DR   PaxDb; Q4V8F4; -.
DR   PRIDE; Q4V8F4; -.
DR   GeneID; 296649; -.
DR   KEGG; rno:296649; -.
DR   UCSC; RGD:1310612; rat.
DR   CTD; 10244; -.
DR   RGD; 1310612; Rabepk.
DR   VEuPathDB; HostDB:ENSRNOG00000018591; -.
DR   eggNOG; KOG0379; Eukaryota.
DR   HOGENOM; CLU_045313_0_0_1; -.
DR   InParanoid; Q4V8F4; -.
DR   OMA; HEWDIPE; -.
DR   OrthoDB; 933937at2759; -.
DR   PhylomeDB; Q4V8F4; -.
DR   TreeFam; TF329153; -.
DR   Reactome; R-RNO-6811440; Retrograde transport at the Trans-Golgi-Network.
DR   PRO; PR:Q4V8F4; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000018591; Expressed in testis and 20 other tissues.
DR   Genevisible; Q4V8F4; RN.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.120.10.80; -; 2.
DR   InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011498; Kelch_2.
DR   Pfam; PF01344; Kelch_1; 1.
DR   Pfam; PF07646; Kelch_2; 1.
DR   SUPFAM; SSF50965; SSF50965; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Kelch repeat; Membrane; Phosphoprotein;
KW   Reference proteome; Repeat.
FT   CHAIN           1..372
FT                   /note="Rab9 effector protein with kelch motifs"
FT                   /id="PRO_0000280618"
FT   REPEAT          49..95
FT                   /note="Kelch 1"
FT   REPEAT          100..146
FT                   /note="Kelch 2"
FT   REPEAT          151..203
FT                   /note="Kelch 3"
FT   REPEAT          204..250
FT                   /note="Kelch 4"
FT   REPEAT          254..303
FT                   /note="Kelch 5"
FT   REPEAT          349..372
FT                   /note="Kelch 6"
FT   REGION          321..342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        324..338
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   372 AA;  40152 MW;  F4BAABB40ECBF031 CRC64;
     MKQLPILEPG DKPRKAAWYT LTCPGDKPCP RVGHSCSYFP PVGEAEKGKV FIVGGANPNQ
     SFSDVHTMDL GTHRWDTATR EGLLPRYEHA SFLPSCSPHS IWVFGGADQS GNRNCLQVMN
     PEARTWSTPE VTGCPPSPRT FHTSSAAIGN HLYVFGGGER GAQPVQDVKL HVFDANTLTW
     AQPETHGSPP SPRHGHAMVA AGTKLFIHGG LAGDRFFDDL HCIDIGDMSW QKLGPTGTAP
     VGCAAHAAVA VGHHVYVFGG MTATGALNTM YKYHTEKQHW TILQFDTSLP PGRLDHSMCV
     IPWPVMSASD TEDSGSVILS LQDEKGDAAE KPETRSGGSR EESPTTLLLC FVFGGMNTEG
     EIYDDCLVTV VD