RABG2_ARATH
ID RABG2_ARATH Reviewed; 212 AA.
AC Q9SJ11; B3H781; Q948K7;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Ras-related protein RABG2;
DE Short=AtRABG2;
DE AltName: Full=Ras-related protein Rab77;
DE Short=AtRab77;
DE AltName: Full=Ras-related protein Rab7a;
DE Short=AtRab7a;
GN Name=RABG2; Synonyms=RAB77, RAB7A; OrderedLocusNames=At2g21880;
GN ORFNames=F7D8.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Ueda T., Wada Y., Nakano A.;
RT "Rab7 homologs in Arabidopsis thaliana.";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12644670; DOI=10.1104/pp.013052;
RA Vernoud V., Horton A.C., Yang Z., Nielsen E.;
RT "Analysis of the small GTPase gene superfamily of Arabidopsis.";
RL Plant Physiol. 131:1191-1208(2003).
CC -!- FUNCTION: Intracellular vesicle trafficking and protein transport.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9SJ11-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9SJ11-2; Sequence=VSP_040947;
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB071852; BAB68377.1; -; mRNA.
DR EMBL; AC007019; AAD20423.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC07233.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07234.1; -; Genomic_DNA.
DR EMBL; BT024593; ABD42991.1; -; mRNA.
DR EMBL; AK229492; BAF01350.1; -; mRNA.
DR EMBL; AY084960; AAM61521.1; -; mRNA.
DR PIR; C84606; C84606.
DR RefSeq; NP_001118357.1; NM_001124885.1. [Q9SJ11-2]
DR RefSeq; NP_565521.1; NM_127757.3. [Q9SJ11-1]
DR AlphaFoldDB; Q9SJ11; -.
DR SMR; Q9SJ11; -.
DR STRING; 3702.AT2G21880.1; -.
DR iPTMnet; Q9SJ11; -.
DR PaxDb; Q9SJ11; -.
DR PRIDE; Q9SJ11; -.
DR ProteomicsDB; 236446; -. [Q9SJ11-1]
DR EnsemblPlants; AT2G21880.1; AT2G21880.1; AT2G21880. [Q9SJ11-1]
DR EnsemblPlants; AT2G21880.2; AT2G21880.2; AT2G21880. [Q9SJ11-2]
DR GeneID; 816724; -.
DR Gramene; AT2G21880.1; AT2G21880.1; AT2G21880. [Q9SJ11-1]
DR Gramene; AT2G21880.2; AT2G21880.2; AT2G21880. [Q9SJ11-2]
DR KEGG; ath:AT2G21880; -.
DR Araport; AT2G21880; -.
DR TAIR; locus:2052479; AT2G21880.
DR eggNOG; KOG0394; Eukaryota.
DR HOGENOM; CLU_041217_10_6_1; -.
DR InParanoid; Q9SJ11; -.
DR OMA; FESVENW; -.
DR PhylomeDB; Q9SJ11; -.
DR PRO; PR:Q9SJ11; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SJ11; baseline and differential.
DR Genevisible; Q9SJ11; AT.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005774; C:vacuolar membrane; IBA:GO_Central.
DR GO; GO:0005773; C:vacuole; HDA:TAIR.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; GTP-binding; Lipoprotein; Membrane;
KW Methylation; Nucleotide-binding; Prenylation; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..212
FT /note="Ras-related protein RABG2"
FT /id="PRO_0000407361"
FT MOTIF 38..46
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 16..23
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 64..68
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 126..129
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 159..160
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 212
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 210
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 212
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT VAR_SEQ 62..69
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_040947"
SQ SEQUENCE 212 AA; 23826 MW; 96E065E0B2D397FC CRC64;
MDSLKNRTLL KVIVLGDSGV GKTSLMNQYV YKKFNKQYKA TIGADFVTKE LHIDEKSVTL
QIWDTAGQER FQSLGAAFYR GADCCVLVYD VNNLKSFETL NNWHTEFLKQ ANPMEPETFP
FVLIGNKTDV DGGNSRVVSN KRAIEWCGSK GNIPYHETSA KEDTNIDEAF LSVAHIALSN
ERKQSNDIYP RGQYHDSVTD IIDPDQSRGC AC
