RABL3_BOVIN
ID RABL3_BOVIN Reviewed; 236 AA.
AC Q32LJ6;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Rab-like protein 3;
GN Name=RABL3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19390049; DOI=10.1126/science.1169588;
RG The bovine genome sequencing and analysis consortium;
RT "The genome sequence of taurine cattle: a window to ruminant biology and
RT evolution.";
RL Science 324:522-528(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Crossbred X Angus, and Hereford; TISSUE=Liver, and Ovary;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-202 (ISOFORM 1).
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Prange C., Schreiber K., Shenmen C., Wagner L.,
RA Liao N., Ali J., Bala M., Barber S., Babakaiff R., Beland J., Chand S.,
RA Chun E., Del Rio L., Gibson S., Matsuo C., Mayo M., Palmquist D., Huang P.,
RA Tsai M., Wong D., Roscoe R., Holt R., Jones S.J., Marra M.A.;
RT "Bovine genome sequencing program: EST and full-length cDNA sequencing.";
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for KRAS signaling regulation and modulation of cell
CC proliferation (By similarity). Regulator of KRAS prenylation, and
CC probably prenylation of other small GTPases (By similarity). Required
CC for lymphocyte development and function (By similarity). Not required
CC for myeloid cell development (By similarity).
CC {ECO:0000250|UniProtKB:Q5HYI8, ECO:0000250|UniProtKB:Q9D4V7}.
CC -!- SUBUNIT: Homodimer (By similarity). Interacts with GPR89; the
CC interaction stabilizes GPR89 (By similarity). Interacts with RAP1GDS1
CC (By similarity). {ECO:0000250|UniProtKB:Q5HYI8,
CC ECO:0000250|UniProtKB:Q9D4V7}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q32LJ6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q32LJ6-2; Sequence=VSP_029722;
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; AAFC03080796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC109545; AAI09546.1; -; mRNA.
DR EMBL; EV660132; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001070274.2; NM_001076806.3. [Q32LJ6-1]
DR AlphaFoldDB; Q32LJ6; -.
DR SMR; Q32LJ6; -.
DR STRING; 9913.ENSBTAP00000021130; -.
DR PaxDb; Q32LJ6; -.
DR PRIDE; Q32LJ6; -.
DR Ensembl; ENSBTAT00000021130; ENSBTAP00000021130; ENSBTAG00000015898. [Q32LJ6-1]
DR GeneID; 505510; -.
DR KEGG; bta:505510; -.
DR CTD; 285282; -.
DR VEuPathDB; HostDB:ENSBTAG00000015898; -.
DR eggNOG; ENOG502QT3S; Eukaryota.
DR GeneTree; ENSGT00390000007467; -.
DR HOGENOM; CLU_084875_1_0_1; -.
DR InParanoid; Q32LJ6; -.
DR OMA; EEIWLNC; -.
DR OrthoDB; 1269342at2759; -.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000015898; Expressed in oocyte and 104 other tissues.
DR GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0030183; P:B cell differentiation; ISS:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0001779; P:natural killer cell differentiation; ISS:UniProtKB.
DR GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR GO; GO:1903059; P:regulation of protein lipidation; ISS:UniProtKB.
DR GO; GO:0046578; P:regulation of Ras protein signal transduction; ISS:UniProtKB.
DR GO; GO:0033077; P:T cell differentiation in thymus; ISS:UniProtKB.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..236
FT /note="Rab-like protein 3"
FT /id="PRO_0000312165"
FT REGION 1..236
FT /note="Small GTPase-like"
FT BINDING 16..21
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q9D4V7"
FT BINDING 148..150
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q9D4V7"
FT BINDING 179..180
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q9D4V7"
FT VAR_SEQ 130..236
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_029722"
SQ SEQUENCE 236 AA; 26383 MW; 6A8E213D76C7AFE2 CRC64;
MASLDRVKVL VLGDSGVGKS SLVHLLCQNQ VLGNPSWTVG CSVDVRVHDY KEGTPEEKTY
YIELWDVGGS VGSASSVKST RAVFYNSVNG IILVHDLTNK KSSQNLYRWS LEALNRDLVP
TGVLVTNGDY DREQFADNQI PLLVIGTKLD QIHENKRHEV LTRTAFLAED FNAEEINLDC
TNPRYLAAGS SNAVKLSRFF DKVIEKRYFL RDGNQIPGFP DRKRFGGGTL KSLHYD
