RABL3_CHICK
ID RABL3_CHICK Reviewed; 230 AA.
AC Q5ZKR4;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Rab-like protein 3;
GN Name=RABL3; ORFNames=RCJMB04_9j2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Required for KRAS signaling regulation and modulation of cell
CC proliferation (By similarity). Regulator of KRAS prenylation, and
CC probably prenylation of other small GTPases (By similarity). Required
CC for lymphocyte development and function (By similarity). Not required
CC for myeloid cell development (By similarity).
CC {ECO:0000250|UniProtKB:Q5HYI8, ECO:0000250|UniProtKB:Q9D4V7}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9D4V7}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; AJ720020; CAG31679.1; -; mRNA.
DR AlphaFoldDB; Q5ZKR4; -.
DR SMR; Q5ZKR4; -.
DR STRING; 9031.ENSGALP00000024069; -.
DR PaxDb; Q5ZKR4; -.
DR VEuPathDB; HostDB:geneid_418329; -.
DR eggNOG; ENOG502QT3S; Eukaryota.
DR InParanoid; Q5ZKR4; -.
DR PhylomeDB; Q5ZKR4; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0030183; P:B cell differentiation; ISS:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0001779; P:natural killer cell differentiation; ISS:UniProtKB.
DR GO; GO:1903059; P:regulation of protein lipidation; ISS:UniProtKB.
DR GO; GO:0046578; P:regulation of Ras protein signal transduction; ISS:UniProtKB.
DR GO; GO:0033077; P:T cell differentiation in thymus; ISS:UniProtKB.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..230
FT /note="Rab-like protein 3"
FT /id="PRO_0000312168"
FT REGION 1..230
FT /note="Small GTPase-like"
FT BINDING 16..21
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q9D4V7"
FT BINDING 148..150
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q9D4V7"
FT BINDING 179..180
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q9D4V7"
SQ SEQUENCE 230 AA; 26002 MW; 8EEE52F1B1023D23 CRC64;
MAALDRVKVL VLGDSGVGKS SLVHLLCHNQ VLGNPSWTVG CSVDVRIHDY KEGTPEEKTY
YIELWDVGGS VGSATSVKST RAVFYNSLNG IILVHDLTNK KSSQNLYRWS LEALNRDVAP
TGVLVTNGDY DREQFADNQI PLLVIGTKLD QIPETKRNEV LTRTAFLAED FNAEEINLDC
TNPRYLAAGS SNAVKLSRFF DKVIEKRYFF KRWQSRFLAS RKERDLEEEH
