ID   RABL3_XENLA             Reviewed;         235 AA.
AC   Q6GPS4;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Rab-like protein 3;
GN   Name=rabl3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for KRAS signaling regulation and modulation of cell
CC       proliferation (By similarity). Regulator of KRAS prenylation, and
CC       probably prenylation of other small GTPases (By similarity). Required
CC       for lymphocyte development and function (By similarity). Not required
CC       for myeloid cell development (By similarity).
CC       {ECO:0000250|UniProtKB:Q5HYI8, ECO:0000250|UniProtKB:Q9D4V7}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9D4V7}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; BC073035; AAH73035.1; -; mRNA.
DR   RefSeq; NP_001085620.1; NM_001092151.1.
DR   AlphaFoldDB; Q6GPS4; -.
DR   SMR; Q6GPS4; -.
DR   MaxQB; Q6GPS4; -.
DR   DNASU; 444046; -.
DR   GeneID; 444046; -.
DR   KEGG; xla:444046; -.
DR   CTD; 444046; -.
DR   Xenbase; XB-GENE-6256255; rabl3.S.
DR   OMA; RYFVEFW; -.
DR   OrthoDB; 1269342at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 444046; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0030183; P:B cell differentiation; ISS:UniProtKB.
DR   GO; GO:0001779; P:natural killer cell differentiation; ISS:UniProtKB.
DR   GO; GO:1903059; P:regulation of protein lipidation; ISS:UniProtKB.
DR   GO; GO:0046578; P:regulation of Ras protein signal transduction; ISS:UniProtKB.
DR   GO; GO:0033077; P:T cell differentiation in thymus; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..235
FT                   /note="Rab-like protein 3"
FT                   /id="PRO_0000312170"
FT   REGION          1..235
FT                   /note="Small GTPase-like"
FT   BINDING         16..21
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D4V7"
FT   BINDING         148..150
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D4V7"
FT   BINDING         179..180
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D4V7"
SQ   SEQUENCE   235 AA;  26181 MW;  9380A3E039C026CD CRC64;
     MASLDRVKVL VLGDSGVGKS SLVHLLCQNQ VLGNPSWTVG CSVDVRLHEY REGTPEEKTY
     YTELWDVGGS VGSASSVKST RAVFYNAVNG IILVHDLTNK KSSQNLYRWS LEALNRDLQP
     MGVLVTNGDY DREQFADNQI PLLVIGTKLD QIPEAKRNEV LTRTAFLAED FNAEEINLDC
     TNTRCLAAGS SNAVKLSRFF DKVIEKRYPR EGNLIPGFSD RKRFGGGNFK SLHYD