ID   RABL3_XENTR             Reviewed;         235 AA.
AC   A4IHM6;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Rab-like protein 3;
GN   Name=rabl3;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for KRAS signaling regulation and modulation of cell
CC       proliferation (By similarity). Regulator of KRAS prenylation, and
CC       probably prenylation of other small GTPases (By similarity). Required
CC       for lymphocyte development and function (By similarity). Not required
CC       for myeloid cell development (By similarity).
CC       {ECO:0000250|UniProtKB:Q5HYI8, ECO:0000250|UniProtKB:Q9D4V7}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9D4V7}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC135594; AAI35595.1; -; mRNA.
DR   RefSeq; NP_001096295.1; NM_001102825.1.
DR   AlphaFoldDB; A4IHM6; -.
DR   SMR; A4IHM6; -.
DR   PaxDb; A4IHM6; -.
DR   DNASU; 100124869; -.
DR   GeneID; 100124869; -.
DR   KEGG; xtr:100124869; -.
DR   CTD; 285282; -.
DR   Xenbase; XB-GENE-6258935; rabl3.
DR   eggNOG; ENOG502QT3S; Eukaryota.
DR   InParanoid; A4IHM6; -.
DR   OrthoDB; 1269342at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0030183; P:B cell differentiation; ISS:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0001779; P:natural killer cell differentiation; ISS:UniProtKB.
DR   GO; GO:1903059; P:regulation of protein lipidation; ISS:UniProtKB.
DR   GO; GO:0046578; P:regulation of Ras protein signal transduction; ISS:UniProtKB.
DR   GO; GO:0033077; P:T cell differentiation in thymus; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..235
FT                   /note="Rab-like protein 3"
FT                   /id="PRO_0000312171"
FT   REGION          1..235
FT                   /note="Small GTPase-like"
FT   BINDING         16..21
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D4V7"
FT   BINDING         148..150
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D4V7"
FT   BINDING         179..180
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D4V7"
SQ   SEQUENCE   235 AA;  26139 MW;  ADB93ED4A763D6E7 CRC64;
     MASLDRVKVL VLGDSGVGKS SLVHLLCQNQ VLGNPSWTVG CSVDVRLHEY REGTPEEKTY
     YIELWDVGGS VGSASSVKST RAVFYNAVNG IILVHDLTNK KSSQNLYRWS LEALNRDLQP
     TGVLVTNGDY DREQFADNQI PLLVIGTKLD QIPEAKRSEV LTRTAFLAED FNAEEINLDC
     TNTRCLAAGS SNAVKLSRFF DKVIEKRYSR EGNLIPGFSD RKRFAGGNFK SLHYD