ID   RABL_MIMIV              Reviewed;         215 AA.
AC   Q5UQ27;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Probable Rab-related GTPase;
DE   Flags: Precursor;
GN   OrderedLocusNames=MIMI_R214;
OS   Acanthamoeba polyphaga mimivirus (APMV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Imitervirales; Mimiviridae; Mimivirus.
OX   NCBI_TaxID=212035;
OH   NCBI_TaxID=5757; Acanthamoeba polyphaga (Amoeba).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rowbotham-Bradford;
RX   PubMed=15486256; DOI=10.1126/science.1101485;
RA   Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H.,
RA   La Scola B., Susan M., Claverie J.-M.;
RT   "The 1.2-megabase genome sequence of Mimivirus.";
RL   Science 306:1344-1350(2004).
CC   -!- FUNCTION: May be involved in protein transport.
CC   -!- SUBCELLULAR LOCATION: Host cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; AY653733; AAV50487.1; -; Genomic_DNA.
DR   PDB; 5XC3; X-ray; 1.50 A; A=9-184.
DR   PDB; 5XC5; X-ray; 1.40 A; A=9-184.
DR   PDBsum; 5XC3; -.
DR   PDBsum; 5XC5; -.
DR   SMR; Q5UQ27; -.
DR   Proteomes; UP000001134; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   1: Evidence at protein level;
KW   3D-structure; GTP-binding; Host cell membrane; Host membrane; Lipoprotein;
KW   Membrane; Methylation; Nucleotide-binding; Prenylation; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..212
FT                   /note="Probable Rab-related GTPase"
FT                   /id="PRO_0000121331"
FT   PROPEP          213..215
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000370840"
FT   MOTIF           42..50
FT                   /note="Effector region"
FT                   /evidence="ECO:0000250"
FT   BINDING         20..27
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         69..73
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         127..130
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         212
FT                   /note="Cysteine methyl ester; by host"
FT                   /evidence="ECO:0000255"
FT   LIPID           211
FT                   /note="S-geranylgeranyl cysteine; by host"
FT                   /evidence="ECO:0000250"
FT   LIPID           212
FT                   /note="S-geranylgeranyl cysteine; by host"
FT                   /evidence="ECO:0000250"
FT   STRAND          14..21
FT                   /evidence="ECO:0007829|PDB:5XC5"
FT   HELIX           26..34
FT                   /evidence="ECO:0007829|PDB:5XC5"
FT   STRAND          49..56
FT                   /evidence="ECO:0007829|PDB:5XC5"
FT   STRAND          62..69
FT                   /evidence="ECO:0007829|PDB:5XC5"
FT   HELIX           74..76
FT                   /evidence="ECO:0007829|PDB:5XC5"
FT   HELIX           77..80
FT                   /evidence="ECO:0007829|PDB:5XC5"
FT   HELIX           81..83
FT                   /evidence="ECO:0007829|PDB:5XC5"
FT   STRAND          88..95
FT                   /evidence="ECO:0007829|PDB:5XC5"
FT   HELIX           99..115
FT                   /evidence="ECO:0007829|PDB:5XC5"
FT   STRAND          121..127
FT                   /evidence="ECO:0007829|PDB:5XC5"
FT   HELIX           133..135
FT                   /evidence="ECO:0007829|PDB:5XC5"
FT   HELIX           140..149
FT                   /evidence="ECO:0007829|PDB:5XC5"
FT   STRAND          153..156
FT                   /evidence="ECO:0007829|PDB:5XC5"
FT   HELIX           162..177
FT                   /evidence="ECO:0007829|PDB:5XC5"
SQ   SEQUENCE   215 AA;  24732 MW;  B5325702EDC2E6F2 CRC64;
     MNSYIKEKME NNGYKIILIG SSGVGKSSIV HQFLFNRKIS NVSPTIGAAF ASKQVIAKNG
     KTLKLNIWDT AGQERFRSIT KMYYTNSLGC LVVFDVTDRE SFDDVYYWIN DLRINCHTTY
     YILVVANKID IDKNNWRVSE NEIKKFCRDN DCDYVFASSF ESDTVNNLFG KMIDKMSEIK
     INPDSRRNDI IYLSDKSSGI DDFIDKISQN CCYIS