ATPA_EMIHU
ID ATPA_EMIHU Reviewed; 499 AA.
AC Q4G397;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=ATP synthase subunit alpha, chloroplastic {ECO:0000255|HAMAP-Rule:MF_01346};
DE EC=7.1.2.2 {ECO:0000255|HAMAP-Rule:MF_01346};
DE AltName: Full=ATP synthase F1 sector subunit alpha {ECO:0000255|HAMAP-Rule:MF_01346};
DE AltName: Full=F-ATPase subunit alpha {ECO:0000255|HAMAP-Rule:MF_01346};
GN Name=atpA {ECO:0000255|HAMAP-Rule:MF_01346};
OS Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi).
OG Plastid; Chloroplast.
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Isochrysidales;
OC Noelaerhabdaceae; Emiliania.
OX NCBI_TaxID=2903;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CCMP373 / CSIRO-CS-57 / BT6;
RX PubMed=16408243; DOI=10.1007/s00239-004-0365-4;
RA Bachvaroff T.R., Sanchez-Puerta M.V., Delwiche C.F.;
RT "Rate variation as a function of gene origin in plastid-derived genes of
RT peridinin-containing dinoflagellates.";
RL J. Mol. Evol. 62:42-52(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP373 / CSIRO-CS-57 / BT6;
RX PubMed=16303746; DOI=10.1093/dnares/12.2.151;
RA Sanchez-Puerta M.V., Bachvaroff T.R., Delwiche C.F.;
RT "The complete plastid genome sequence of the haptophyte Emiliania huxleyi:
RT a comparison to other plastid genomes.";
RL DNA Res. 12:151-156(2005).
CC -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC across the membrane. The alpha chain is a regulatory subunit.
CC {ECO:0000255|HAMAP-Rule:MF_01346}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate;
CC Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01346};
CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC - and CF(0) - the membrane proton channel. CF(1) has five subunits:
CC alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main
CC subunits: a, b, b' and c. {ECO:0000255|HAMAP-Rule:MF_01346}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane
CC {ECO:0000255|HAMAP-Rule:MF_01346}; Peripheral membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_01346}.
CC -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC {ECO:0000255|HAMAP-Rule:MF_01346}.
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DR EMBL; AY675516; AAU81898.1; -; Genomic_DNA.
DR EMBL; AY741371; AAX13869.1; -; Genomic_DNA.
DR RefSeq; YP_277370.1; NC_007288.1.
DR AlphaFoldDB; Q4G397; -.
DR SMR; Q4G397; -.
DR GeneID; 3562446; -.
DR Proteomes; UP000013827; Unassembled WGS sequence.
DR GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045261; C:proton-transporting ATP synthase complex, catalytic core F(1); IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-EC.
DR CDD; cd18113; ATP-synt_F1_alpha_C; 1.
DR CDD; cd01132; F1_ATPase_alpha; 1.
DR Gene3D; 1.20.150.20; -; 1.
DR Gene3D; 2.40.30.20; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01346; ATP_synth_alpha_bact; 1.
DR InterPro; IPR023366; ATP_synth_asu-like_sf.
DR InterPro; IPR000793; ATP_synth_asu_C.
DR InterPro; IPR038376; ATP_synth_asu_C_sf.
DR InterPro; IPR033732; ATP_synth_F1_a.
DR InterPro; IPR005294; ATP_synth_F1_asu.
DR InterPro; IPR020003; ATPase_a/bsu_AS.
DR InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N.
DR InterPro; IPR036121; ATPase_F1/V1/A1_a/bsu_N_sf.
DR InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00006; ATP-synt_ab; 1.
DR Pfam; PF00306; ATP-synt_ab_C; 1.
DR Pfam; PF02874; ATP-synt_ab_N; 1.
DR PIRSF; PIRSF039088; F_ATPase_subunit_alpha; 1.
DR SUPFAM; SSF50615; SSF50615; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00962; atpA; 1.
DR PROSITE; PS00152; ATPASE_ALPHA_BETA; 1.
PE 3: Inferred from homology;
KW ATP synthesis; ATP-binding; CF(1); Chloroplast; Hydrogen ion transport;
KW Ion transport; Membrane; Nucleotide-binding; Plastid; Reference proteome;
KW Thylakoid; Translocase; Transport.
FT CHAIN 1..499
FT /note="ATP synthase subunit alpha, chloroplastic"
FT /id="PRO_0000238420"
FT BINDING 170..177
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01346"
FT SITE 363
FT /note="Required for activity"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01346"
SQ SEQUENCE 499 AA; 53427 MW; D6EDA7A3C7B7D6D6 CRC64;
MINIRPDEIS NIIRQQIESY DQEVQIDNVG TVLQIGDGIA RVYGLEQVMA GELLEFDDST
VGIALNLEND NVGAVLMGPG LGILEGSAVR STGKIAQVPV GDAFLGRVVN SLAKPIDGKG
DIPASETRLV ESMAPGIITR KSVCEPVQTG ITAIDSMIPI GRGQRELIIG DRQTGKTSVA
IDTIINQKTE DVICVYVAIG QKASSVAGVV STLEDKGALG YTIIVAANAD EPATLQYIAP
YTGAALAEYF MYKGKATVIV YDDLTKQASA YRQMSLLLRR PPGREAYPGD VFYLHSRLLE
RAAKLSDALG GGSMTALPII ETQAGDVSAY IPTNVISITD GQIFLSGDLF NSGIRPAINV
GISVSRVGSA AQTKAMKQVA GKLKLELAQF AELEAFSQFA SDLDAATQAE LARGVRLREM
LKQKQNSPIS VEEQVAIIYA GINGYLDTIP VSEVKGFVEK LRSYLRNSAP QFISSIQSEK
KLSPENEELL KKILTDLKG
