ID   RABS_DICDI              Reviewed;         221 AA.
AC   Q54SD0;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Ras-related protein RabS;
DE   Flags: Precursor;
GN   Name=rabS; ORFNames=DDB_G0282537;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000047; EAL66128.1; -; Genomic_DNA.
DR   RefSeq; XP_640109.1; XM_635017.1.
DR   AlphaFoldDB; Q54SD0; -.
DR   SMR; Q54SD0; -.
DR   STRING; 44689.DDB0230041; -.
DR   PaxDb; Q54SD0; -.
DR   EnsemblProtists; EAL66128; EAL66128; DDB_G0282537.
DR   GeneID; 8623640; -.
DR   KEGG; ddi:DDB_G0282537; -.
DR   dictyBase; DDB_G0282537; rabS.
DR   eggNOG; KOG0084; Eukaryota.
DR   HOGENOM; CLU_041217_10_1_1; -.
DR   InParanoid; Q54SD0; -.
DR   OMA; WIGVEFR; -.
DR   PhylomeDB; Q54SD0; -.
DR   PRO; PR:Q54SD0; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0031164; C:contractile vacuolar membrane; IDA:dictyBase.
DR   GO; GO:0000139; C:Golgi membrane; IDA:dictyBase.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:2001135; P:regulation of endocytic recycling; IMP:dictyBase.
DR   GO; GO:0090182; P:regulation of secretion of lysosomal enzymes; IMP:dictyBase.
DR   GO; GO:0006970; P:response to osmotic stress; IMP:dictyBase.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation;
KW   Nucleotide-binding; Prenylation; Reference proteome.
FT   CHAIN           1..218
FT                   /note="Ras-related protein RabS"
FT                   /id="PRO_0000332768"
FT   PROPEP          219..221
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000370836"
FT   MOTIF           38..47
FT                   /note="Effector region"
FT                   /evidence="ECO:0000250"
FT   BINDING         16..23
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         71..75
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         137..140
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         218
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000255"
FT   LIPID           218
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   221 AA;  25288 MW;  114632D6B4839654 CRC64;
     MAKMDHDYRL NIVLVGDNQC GKSFLLSRYC DGMFVENGIQ LWHGIEIKNK IIELKNQSTN
     EIVKVKLMIF DGNGGCKFKE LFYENYLKHQ HGFIIMYDVT NLESFNNLSN WISKIKNSYQ
     TSNLYPSPEP ILFIVGNKCD LIDDSKITTI VDLKKPQEFC DSLSIPSIHN VSVKENINVD
     LIFQKLSQLI MDTYPPPKIS EIKKIKNVDS GGDSINNCII N