ID   RAC13_GOSHI             Reviewed;         196 AA.
AC   Q41253;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Rac-like GTP-binding protein RAC13;
DE   Flags: Precursor;
GN   Name=RAC13;
OS   Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX   NCBI_TaxID=3635;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Acala SJ2;
RX   PubMed=7651326; DOI=10.1007/bf02456612;
RA   Delmer D.P., Pear J.R., Andrawis A., Stalker D.M.;
RT   "Genes encoding small GTP-binding proteins analogous to mammalian rac are
RT   preferentially expressed in developing cotton fibers.";
RL   Mol. Gen. Genet. 248:43-51(1995).
CC   -!- FUNCTION: Could participate in a signal transduction pathway that
CC       controls cytoskeletal organization.
CC   -!- FUNCTION: Inactive GDP-bound Rho GTPases reside in the cytosol, are
CC       found in a complex with Rho GDP-dissociation inhibitors (Rho GDIs), and
CC       are released from the GDI protein in order to translocate to membranes
CC       upon activation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}. Note=Associated with the
CC       membrane when activated.
CC   -!- DEVELOPMENTAL STAGE: Highly enhanced expression in developing cotton
CC       fibers, with maximal expression occurring at the time of transition
CC       between primary and secondary wall synthesis.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; S79308; AAB35093.1; -; mRNA.
DR   PIR; S57325; S57325.
DR   RefSeq; XP_016710996.1; XM_016855507.1.
DR   AlphaFoldDB; Q41253; -.
DR   SMR; Q41253; -.
DR   GeneID; 107924928; -.
DR   KEGG; ghi:107924928; -.
DR   OMA; NIMEKWH; -.
DR   Proteomes; UP000189702; Unplaced.
DR   GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR   GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR   GO; GO:0030865; P:cortical cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007163; P:establishment or maintenance of cell polarity; IBA:GO_Central.
DR   GO; GO:0009834; P:plant-type secondary cell wall biogenesis; TAS:AgBase.
DR   GO; GO:0032956; P:regulation of actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR   GO; GO:0090379; P:secondary cell wall biogenesis involved in seed trichome differentiation; IEP:AgBase.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   PANTHER; PTHR24072; PTHR24072; 1.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Lipoprotein; Membrane; Methylation;
KW   Nucleotide-binding; Prenylation; Reference proteome.
FT   CHAIN           1..193
FT                   /note="Rac-like GTP-binding protein RAC13"
FT                   /id="PRO_0000198928"
FT   PROPEP          194..196
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000227590"
FT   MOTIF           35..43
FT                   /note="Effector region"
FT                   /evidence="ECO:0000255"
FT   BINDING         13..20
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         60..64
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         118..121
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         193
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000255"
FT   LIPID           193
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   196 AA;  21800 MW;  5251903223CDD4F4 CRC64;
     MSTARFIKCV TVGDGAVGKT CMLISYTSNT FPTDYVPTVF DNFSANVVVD GSTVNLGLWD
     TAGQEDYNRL RPLSYRGADV FLLAFSLISK ASYENIYKKW IPELRHYAHN VPVVLVGTKL
     DLRDDKQFLI DHPGATPIST SQGEELKKMI GAVTYIECSS KTQQNVKAVF DAAIKVALRP
     PKPKRKPCKR RTCAFL