RACA_GEOKA
ID RACA_GEOKA Reviewed; 172 AA.
AC Q5KVB2;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Chromosome-anchoring protein RacA {ECO:0000255|HAMAP-Rule:MF_01170};
GN Name=racA {ECO:0000255|HAMAP-Rule:MF_01170}; OrderedLocusNames=GK3089;
OS Geobacillus kaustophilus (strain HTA426).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC Geobacillus thermoleovorans group.
OX NCBI_TaxID=235909;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTA426;
RX PubMed=15576355; DOI=10.1093/nar/gkh970;
RA Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H.,
RA Matsui S., Uchiyama I.;
RT "Thermoadaptation trait revealed by the genome sequence of thermophilic
RT Geobacillus kaustophilus.";
RL Nucleic Acids Res. 32:6292-6303(2004).
CC -!- FUNCTION: Required for the formation of axial filaments and for
CC anchoring the origin regions at the cell poles in sporulating cells,
CC thus ensuring proper chromosome segregation in the prespore. Binds in a
CC dispersed manner throughout the chromosome but preferentially to sites
CC clustered in the origin portion of the chromosome, causing condensation
CC of the chromosome and its remodeling into an elongated, anchored
CC structure. {ECO:0000255|HAMAP-Rule:MF_01170}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01170}.
CC Note=Localizes to cell poles and nucleoid. {ECO:0000255|HAMAP-
CC Rule:MF_01170}.
CC -!- SIMILARITY: Belongs to the RacA family. {ECO:0000255|HAMAP-
CC Rule:MF_01170}.
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DR EMBL; BA000043; BAD77374.1; -; Genomic_DNA.
DR RefSeq; WP_011232559.1; NC_006510.1.
DR AlphaFoldDB; Q5KVB2; -.
DR SMR; Q5KVB2; -.
DR STRING; 235909.GK3089; -.
DR PRIDE; Q5KVB2; -.
DR EnsemblBacteria; BAD77374; BAD77374; GK3089.
DR KEGG; gka:GK3089; -.
DR eggNOG; COG0789; Bacteria.
DR HOGENOM; CLU_111022_0_0_9; -.
DR OMA; WVKQLNL; -.
DR Proteomes; UP000001172; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008356; P:asymmetric cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-UniRule.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01170; RacA; 1.
DR InterPro; IPR023522; Chrosome_anchoring_RacA.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR Pfam; PF13411; MerR_1; 1.
DR SUPFAM; SSF46955; SSF46955; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Chromosome partition; Coiled coil; Cytoplasm;
KW DNA-binding; Reference proteome; Sporulation.
FT CHAIN 1..172
FT /note="Chromosome-anchoring protein RacA"
FT /id="PRO_0000224158"
FT DNA_BIND 5..25
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01170"
FT REGION 57..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 83..146
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01170"
SQ SEQUENCE 172 AA; 19764 MW; 05E208708EC7C047 CRC64;
MELKTSDVAI RLGVSPKTIQ RWVRKYNIPL RRNEAGHYLF DEKTVALLER VKFEQGAAME
APPTPKRPPT PLRNNIPIDA LHESIEPEIA RVSSRLDQLE RQLEQKADDV VSIQLLHHRQ
EMEEIVARLT ALEQLVARLE QQLNNRPPSS HETSDEPKQK RRGLGRVMGL FA
