ID   RACC_ENTHI              Reviewed;         194 AA.
AC   Q24816;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Rho-related protein racC;
DE   Flags: Precursor;
GN   Name=RACC;
OS   Entamoeba histolytica.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=5759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 30459 / HM-1:IMSS;
RX   PubMed=8964500; DOI=10.1016/0378-1119(96)00232-6;
RA   Lohia A., Samuelson J.;
RT   "Heterogeneity of Entamoeba histolytica rac genes encoding p21rac
RT   homologues.";
RL   Gene 173:205-208(1996).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC       {ECO:0000305}.
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DR   EMBL; U29722; AAC47298.1; -; Genomic_DNA.
DR   PIR; JC4932; JC4932.
DR   PDB; 4MIT; X-ray; 2.35 A; A/B/C/D=1-183.
DR   PDBsum; 4MIT; -.
DR   AlphaFoldDB; Q24816; -.
DR   SMR; Q24816; -.
DR   DIP; DIP-60102N; -.
DR   IntAct; Q24816; 1.
DR   STRING; 5759.rna_EHI_070730-1; -.
DR   VEuPathDB; AmoebaDB:EHI5A_060860; -.
DR   VEuPathDB; AmoebaDB:EHI7A_090820; -.
DR   VEuPathDB; AmoebaDB:EHI8A_093900; -.
DR   VEuPathDB; AmoebaDB:EHI_070730; -.
DR   VEuPathDB; AmoebaDB:KM1_331620; -.
DR   eggNOG; KOG0393; Eukaryota.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   PANTHER; PTHR24072; PTHR24072; 1.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; GTP-binding; Lipoprotein; Membrane;
KW   Methylation; Nucleotide-binding; Prenylation.
FT   CHAIN           1..191
FT                   /note="Rho-related protein racC"
FT                   /id="PRO_0000198912"
FT   PROPEP          192..194
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000281260"
FT   MOTIF           36..44
FT                   /note="Effector region"
FT                   /evidence="ECO:0000255"
FT   BINDING         14..21
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         61..65
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         119..122
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         191
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250"
FT   LIPID           191
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
FT   STRAND          6..15
FT                   /evidence="ECO:0007829|PDB:4MIT"
FT   HELIX           20..29
FT                   /evidence="ECO:0007829|PDB:4MIT"
FT   STRAND          40..50
FT                   /evidence="ECO:0007829|PDB:4MIT"
FT   STRAND          53..62
FT                   /evidence="ECO:0007829|PDB:4MIT"
FT   HELIX           66..68
FT                   /evidence="ECO:0007829|PDB:4MIT"
FT   TURN            69..71
FT                   /evidence="ECO:0007829|PDB:4MIT"
FT   HELIX           72..75
FT                   /evidence="ECO:0007829|PDB:4MIT"
FT   STRAND          80..87
FT                   /evidence="ECO:0007829|PDB:4MIT"
FT   HELIX           91..99
FT                   /evidence="ECO:0007829|PDB:4MIT"
FT   HELIX           101..108
FT                   /evidence="ECO:0007829|PDB:4MIT"
FT   STRAND          114..119
FT                   /evidence="ECO:0007829|PDB:4MIT"
FT   HELIX           121..123
FT                   /evidence="ECO:0007829|PDB:4MIT"
FT   HELIX           127..135
FT                   /evidence="ECO:0007829|PDB:4MIT"
FT   HELIX           143..152
FT                   /evidence="ECO:0007829|PDB:4MIT"
FT   STRAND          156..160
FT                   /evidence="ECO:0007829|PDB:4MIT"
FT   TURN            163..165
FT                   /evidence="ECO:0007829|PDB:4MIT"
FT   HELIX           169..181
FT                   /evidence="ECO:0007829|PDB:4MIT"
SQ   SEQUENCE   194 AA;  21595 MW;  8D1DCD5D64F16696 CRC64;
     MSEKPTSIKL VVVGDGAVGK TCLLICYTTN EFPKDYIPTV FDNYVVSLTA GTRQIQLALW
     DTAGQEEYDQ LRPLSYSSAS IFLICFSVTS SVSYDNVITK WHPEVIHFAP KVPIILVGTK
     LDTRNDPAIV KRLTEQGMTV INTAKGEELK NRIKAVKYIE CSAKTSENLK TVFDEAVKTV
     LMNKPQQRSK CALL