RACK1_CHICK
ID RACK1_CHICK Reviewed; 317 AA.
AC P63247; A5HUK6; P25388; P99049; Q5EVY1;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Receptor of activated protein C kinase 1;
DE AltName: Full=Guanine nucleotide-binding protein subunit beta-like protein 12.3;
DE AltName: Full=Receptor for activated C kinase;
DE AltName: Full=Receptor of activated protein kinase C 1;
DE Short=RACK1;
GN Name=RACK1; Synonyms=GNB2L1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=2499885; DOI=10.1073/pnas.86.12.4594;
RA Guillemot F., Billault A., Auffray C.;
RT "Physical linkage of a guanine nucleotide-binding protein-related gene to
RT the chicken major histocompatibility complex.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:4594-4598(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=15128875; DOI=10.1093/molbev/msh150;
RA Takezaki N., Figueroa F., Zaleska-Rutczynska Z., Takahata N., Klein J.;
RT "The phylogenetic relationship of tetrapod, coelacanth, and lungfish
RT revealed by the sequences of forty-four nuclear genes.";
RL Mol. Biol. Evol. 21:1512-1524(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15744538; DOI=10.1007/s00251-005-0770-x;
RA Ruby T., Bed'Hom B., Wittzell H., Morin V., Oudin A., Zoorob R.;
RT "Characterisation of a cluster of TRIM-B30.2 genes in the chicken MHC B
RT locus.";
RL Immunogenetics 57:116-128(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=17513765; DOI=10.4049/jimmunol.178.11.7162;
RA Shiina T., Briles W.E., Goto R.M., Hosomichi K., Yanagiya K., Shimizu S.,
RA Inoko H., Miller M.M.;
RT "Extended gene map reveals tripartite motif, C-type lectin, and Ig
RT superfamily type genes within a subregion of the chicken MHC-B affecting
RT infectious disease.";
RL J. Immunol. 178:7162-7172(2007).
CC -!- FUNCTION: Involved in the recruitment, assembly and/or regulation of a
CC variety of signaling molecules. Interacts with a wide variety of
CC proteins and plays a role in many cellular processes (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P63244};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:P63244}. Cytoplasm
CC {ECO:0000250|UniProtKB:P63244}. Cytoplasm, perinuclear region
CC {ECO:0000250|UniProtKB:P63244}. Nucleus {ECO:0000250|UniProtKB:P63244}.
CC Perikaryon {ECO:0000250|UniProtKB:P68040}. Cell projection, dendrite
CC {ECO:0000250|UniProtKB:P68040}. Note=Recruited to the plasma membrane
CC through interaction with KRT1 which binds to membrane-bound ITGB1. Also
CC associated with the membrane in oncogene-transformed cells. PKC
CC activation induces translocation from the perinuclear region to the
CC cell periphery (By similarity). In the brain, detected mainly in cell
CC bodies and dendrites with little expression in axonal fibers or nuclei
CC (By similarity). {ECO:0000250|UniProtKB:P63244,
CC ECO:0000250|UniProtKB:P68040}.
CC -!- SIMILARITY: Belongs to the WD repeat G protein beta family. Ribosomal
CC protein RACK1 subfamily. {ECO:0000305}.
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DR EMBL; M24193; AAA50559.1; -; mRNA.
DR EMBL; AY393848; AAS49613.1; -; mRNA.
DR EMBL; AY694127; AAW82329.1; -; Genomic_DNA.
DR EMBL; AB268588; BAF62990.1; -; Genomic_DNA.
DR PIR; A33928; A33928.
DR RefSeq; NP_001004378.1; NM_001004378.2.
DR AlphaFoldDB; P63247; -.
DR SMR; P63247; -.
DR BioGRID; 678470; 1.
DR STRING; 9031.ENSGALP00000000170; -.
DR PaxDb; P63247; -.
DR Ensembl; ENSGALT00000000171; ENSGALP00000000170; ENSGALG00000000122.
DR GeneID; 417044; -.
DR KEGG; gga:417044; -.
DR CTD; 10399; -.
DR VEuPathDB; HostDB:geneid_417044; -.
DR eggNOG; KOG0279; Eukaryota.
DR GeneTree; ENSGT00940000154461; -.
DR HOGENOM; CLU_000288_57_7_1; -.
DR InParanoid; P63247; -.
DR OMA; CKAMLWD; -.
DR OrthoDB; 805365at2759; -.
DR PhylomeDB; P63247; -.
DR Reactome; R-GGA-5626978; TNFR1-mediated ceramide production.
DR PRO; PR:P63247; -.
DR Proteomes; UP000000539; Chromosome 16.
DR Bgee; ENSGALG00000000122; Expressed in granulocyte and 12 other tissues.
DR ExpressionAtlas; P63247; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0043025; C:neuronal cell body; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR GO; GO:0005080; F:protein kinase C binding; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:2000543; P:positive regulation of gastrulation; ISS:UniProtKB.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR GO; GO:0051302; P:regulation of cell division; ISS:UniProtKB.
DR GO; GO:2000114; P:regulation of establishment of cell polarity; ISS:UniProtKB.
DR GO; GO:0032880; P:regulation of protein localization; ISS:UniProtKB.
DR GO; GO:0072344; P:rescue of stalled ribosome; ISS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; TAS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR045223; Asc1/RACK1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19868; PTHR19868; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cell membrane; Cell projection; Cytoplasm; Membrane; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosomal protein; WD repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..317
FT /note="Receptor of activated protein C kinase 1"
FT /id="PRO_0000127735"
FT REPEAT 13..44
FT /note="WD 1"
FT REPEAT 61..91
FT /note="WD 2"
FT REPEAT 103..133
FT /note="WD 3"
FT REPEAT 146..178
FT /note="WD 4"
FT REPEAT 190..220
FT /note="WD 5"
FT REPEAT 231..260
FT /note="WD 6"
FT REPEAT 281..311
FT /note="WD 7"
FT MOD_RES 2
FT /note="N-acetylthreonine"
FT /evidence="ECO:0000250"
FT MOD_RES 228
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 317 AA; 35077 MW; 257F91E369ED2044 CRC64;
MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET NYGIPQRALR
GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR FVGHTKDVLS VAFSSDNRQI
VSGSRDKTIK LWNTLGVCKY TVQDESHSEW VSCVRFSPNS SNPIIVSCGW DKLVKVWNLA
NCKLKTNHIG HTGYLNTVTV SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DGGDIINALC
FSPNRYWLCA ATGPSIKIWD LEGKIIVDEL KQEVISTSSK AEPPQCTSLA WSADGQTLFA
GYTDNLVRVW QVTIGTR
