ID   RAD17_ASHGO             Reviewed;         389 AA.
AC   Q758W7;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=DNA damage checkpoint control protein RAD17;
GN   Name=RAD17; OrderedLocusNames=ADR411W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the checkpoint clamp complex involved in the
CC       surveillance mechanism that allows the DNA repair pathways to act to
CC       restore the integrity of the DNA prior to DNA synthesis or separation
CC       of the replicated chromosomes. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the checkpoint clamp complex composed of DDC1,
CC       MEC3 and RAD17. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the rad1 family. {ECO:0000305}.
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DR   EMBL; AE016817; AAS52330.1; -; Genomic_DNA.
DR   RefSeq; NP_984506.1; NM_209859.1.
DR   AlphaFoldDB; Q758W7; -.
DR   SMR; Q758W7; -.
DR   STRING; 33169.AAS52330; -.
DR   EnsemblFungi; AAS52330; AAS52330; AGOS_ADR411W.
DR   GeneID; 4620671; -.
DR   KEGG; ago:AGOS_ADR411W; -.
DR   eggNOG; KOG3194; Eukaryota.
DR   HOGENOM; CLU_057555_0_0_1; -.
DR   InParanoid; Q758W7; -.
DR   OMA; VHLEHIT; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0030896; C:checkpoint clamp complex; IBA:GO_Central.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0000077; P:DNA damage checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0006302; P:double-strand break repair; IEA:EnsemblFungi.
DR   GO; GO:0007131; P:reciprocal meiotic recombination; IEA:EnsemblFungi.
DR   InterPro; IPR016587; Rad17.
DR   InterPro; IPR003021; Rad1_Rec1_Rad17.
DR   PANTHER; PTHR10870; PTHR10870; 1.
DR   Pfam; PF02144; Rad1; 1.
DR   PIRSF; PIRSF011769; Cell_cycle_RAD17; 1.
DR   PRINTS; PR01245; RAD1REC1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; DNA-binding; Hydrolase; Nuclease; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..389
FT                   /note="DNA damage checkpoint control protein RAD17"
FT                   /id="PRO_0000239640"
FT   REGION          358..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   389 AA;  43153 MW;  2FFFC0AA27E7F7CC CRC64;
     MLESTALFSA TTIHLDRLMC AFNCMTPFGQ RDDVLITIDR DGLTFIRQNN HAAEIQLFLA
     KELFQYYSIR EGFEGEIQLC MKLNHLLDTV SVANRDKDDV VECTLSYDGE GTPFMLILED
     SMITEQVEYA TYLVGEMDRT GLELDRARLE FECILKGDVL YSALRDLREI GCKECYLYIV
     TSSRARPMFA LVSRGQLGLS KIILPSERSV LEKLEVYEND STTLIHDAPV IGLFDFAALD
     KLRPSTKIAS KVLIRKDVHG LLAVNILSDT NAILVPEKRE LIRASRSVSA EYPTVVIEVF
     LLEKASVGDI DVRDVHQLML TSPAHRRSGF ADSGSRIVSV TPTATSAAHT GAGSLLGLAP
     PSAFPAEETQ DPDESYHPAP SNTDIPLFL