ID   RAD1_SCHPO              Reviewed;         323 AA.
AC   P22193;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 2.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=DNA damage checkpoint control protein rad1;
GN   Name=rad1; ORFNames=SPAC1952.07;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2355921; DOI=10.1128/mcb.10.7.3750-3760.1990;
RA   Sunnerhagen P., Seaton B.L., Nasim A., Subramani S.;
RT   "Cloning and analysis of a gene involved in DNA repair and recombination,
RT   the rad1 gene of Schizosaccharomyces pombe.";
RL   Mol. Cell. Biol. 10:3750-3760(1990).
RN   [2]
RP   SEQUENCE REVISION.
RX   PubMed=8202381; DOI=10.1093/nar/22.9.1750;
RA   Zhang M.Q., Marr T.G.;
RT   "Fission yeast gene structure and recognition.";
RL   Nucleic Acids Res. 22:1750-1759(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=7926829; DOI=10.1016/0378-1119(94)90250-x;
RA   Long K.E., Sunnerhagen P., Subramani S.;
RT   "The Schizosaccharomyces pombe rad1 gene consists of three exons and the
RT   cDNA sequence is partially homologous to the Ustilago maydis REC1 cDNA.";
RL   Gene 148:155-159(1994).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Recombinational reparation of DNA damages induced by UV and
CC       gamma radiation.
CC   -!- INTERACTION:
CC       P22193; Q10159: myh1; NbExp=2; IntAct=EBI-767637, EBI-767574;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the rad1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA35329.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; M38132; AAA35329.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; Z28385; CAA82231.1; -; mRNA.
DR   EMBL; CU329670; CAB52571.1; -; Genomic_DNA.
DR   PIR; JC2578; JC2578.
DR   RefSeq; NP_594809.1; NM_001020238.2.
DR   AlphaFoldDB; P22193; -.
DR   SMR; P22193; -.
DR   BioGRID; 279014; 118.
DR   IntAct; P22193; 1.
DR   STRING; 4896.SPAC1952.07.1; -.
DR   iPTMnet; P22193; -.
DR   MaxQB; P22193; -.
DR   PaxDb; P22193; -.
DR   PRIDE; P22193; -.
DR   EnsemblFungi; SPAC1952.07.1; SPAC1952.07.1:pep; SPAC1952.07.
DR   GeneID; 2542558; -.
DR   KEGG; spo:SPAC1952.07; -.
DR   PomBase; SPAC1952.07; rad1.
DR   VEuPathDB; FungiDB:SPAC1952.07; -.
DR   eggNOG; KOG3194; Eukaryota.
DR   HOGENOM; CLU_035332_0_0_1; -.
DR   InParanoid; P22193; -.
DR   OMA; QITMSPE; -.
DR   PhylomeDB; P22193; -.
DR   Reactome; R-SPO-176187; Activation of ATR in response to replication stress.
DR   PRO; PR:P22193; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0030896; C:checkpoint clamp complex; IDA:PomBase.
DR   GO; GO:0140445; C:chromosome, telomeric repeat region; IDA:PomBase.
DR   GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; IDA:PomBase.
DR   GO; GO:0035861; C:site of double-strand break; IDA:PomBase.
DR   GO; GO:0000077; P:DNA damage checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0033315; P:meiotic G2/MI DNA replication checkpoint signaling; IMP:PomBase.
DR   GO; GO:0033314; P:mitotic DNA replication checkpoint signaling; IMP:PomBase.
DR   GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; IMP:PomBase.
DR   GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IMP:PomBase.
DR   GO; GO:0000723; P:telomere maintenance; IMP:PomBase.
DR   InterPro; IPR003011; Cell_cycle_checkpoint_Rad1.
DR   InterPro; IPR003021; Rad1_Rec1_Rad17.
DR   PANTHER; PTHR10870; PTHR10870; 1.
DR   Pfam; PF02144; Rad1; 1.
DR   PRINTS; PR01245; RAD1REC1.
DR   PRINTS; PR01246; RAD1REPAIR.
PE   1: Evidence at protein level;
KW   DNA damage; DNA repair; Nucleus; Reference proteome.
FT   CHAIN           1..323
FT                   /note="DNA damage checkpoint control protein rad1"
FT                   /id="PRO_0000097151"
FT   REGION          284..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        284..298
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   323 AA;  36528 MW;  1A2A4DEFC3A55EE6 CRC64;
     MFQAETVCLK QIQSTLRCID FSKECTIEIT SRGLRFAVEE SQSLQAHAFL DKSLFQTFNF
     QGDSDGDTYM FQTMISPLLQ SLSIYTDGKE RISTSAWDQP TVNIMHKRGV ICKVQYNGPG
     CPFIWEVEEM AGYATACELL TMECEDDVDI NRLASTLCTK IIMKSNWLYD ALVELDNNMG
     ENLIIHTSSQ KSTFLLRCVG ALSTTEIEYP NEKSVLESFE TDSENTYSYR FSLIRHALKA
     LQVGSKVNLR IDENGTLSIQ IMLVGQEGLC TFVDFCIVPL DLVSEDEEED EEEEPAESNQ
     SDNNVLRNDP NYRGDAETED EDS