ID   RAD26_SCHPO             Reviewed;         614 AA.
AC   P36632; O14292;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   25-MAY-2022, entry version 123.
DE   RecName: Full=DNA repair protein rad26;
GN   Name=rad26; ORFNames=SPAC9E9.08;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8019001; DOI=10.1091/mbc.5.2.147;
RA   Al-Khodairy F., Fotou E., Sheldrick K.S., Griffiths D.J.F., Lehmann A.R.,
RA   Carr A.M.;
RT   "Identification and characterization of new elements involved in checkpoint
RT   and feedback controls in fission yeast.";
RL   Mol. Biol. Cell 5:147-160(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [3]
RP   INTERACTION WITH CDS1.
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=9450932; DOI=10.1101/gad.12.3.382;
RA   Lindsay H.D., Griffiths D.J.F., Edwards R.J., Christensen P.U.,
RA   Murray J.M., Osman F., Walworth N., Carr A.M.;
RT   "S-phase-specific activation of Cds1 kinase defines a subpathway of the
RT   checkpoint response in Schizosaccharomyces pombe.";
RL   Genes Dev. 12:382-395(1998).
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=12697061; DOI=10.1186/1471-2156-4-6;
RA   Wolkow T.D., Enoch T.;
RT   "Fission yeast Rad26 responds to DNA damage independently of Rad3.";
RL   BMC Genet. 4:6-6(2003).
CC   -!- FUNCTION: Involved in cell cycle arrest when DNA synthesis is inhibited
CC       by hydroxyurea, and in mitosis arrest after treatment with DNA-damaging
CC       agents. This protein is S phase-specific.
CC   -!- SUBUNIT: Interacts with cds1. {ECO:0000269|PubMed:9450932}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12697061}.
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DR   EMBL; X76558; CAA54058.1; -; Genomic_DNA.
DR   EMBL; CU329670; CAB16406.1; -; Genomic_DNA.
DR   PIR; S42797; S42797.
DR   PIR; T39215; T39215.
DR   RefSeq; NP_594581.1; NM_001020010.2.
DR   AlphaFoldDB; P36632; -.
DR   SMR; P36632; -.
DR   BioGRID; 279714; 109.
DR   IntAct; P36632; 1.
DR   STRING; 4896.SPAC9E9.08.1; -.
DR   MaxQB; P36632; -.
DR   PaxDb; P36632; -.
DR   PRIDE; P36632; -.
DR   EnsemblFungi; SPAC9E9.08.1; SPAC9E9.08.1:pep; SPAC9E9.08.
DR   PomBase; SPAC9E9.08; rad26.
DR   VEuPathDB; FungiDB:SPAC9E9.08; -.
DR   HOGENOM; CLU_444924_0_0_1; -.
DR   OMA; SYCASIK; -.
DR   PRO; PR:P36632; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0070310; C:ATR-ATRIP complex; IDA:PomBase.
DR   GO; GO:0140445; C:chromosome, telomeric repeat region; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; IDA:PomBase.
DR   GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IMP:PomBase.
DR   GO; GO:0070198; P:protein localization to chromosome, telomeric region; IGI:PomBase.
DR   GO; GO:0000723; P:telomere maintenance; IMP:PomBase.
DR   InterPro; IPR018622; DNA_damage_chkpnt_Lcd1.
DR   Pfam; PF09798; LCD1; 2.
PE   1: Evidence at protein level;
KW   Cell cycle; DNA damage; Nucleus; Reference proteome.
FT   CHAIN           1..614
FT                   /note="DNA repair protein rad26"
FT                   /id="PRO_0000097152"
FT   REGION          29..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          157..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        157..181
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        159..164
FT                   /note="MKRDVK -> NEKRCKR (in Ref. 1; CAA54058)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   614 AA;  68921 MW;  4B8D93C3CB97C672 CRC64;
     MMADESFDLE SLGSDEIFEG VNLDELEQQA QTQVQAQSSQ VVVPSEKQKQ NLNLPNSYTN
     SSQKVRESTV NSQASLSSND LRTELLIKSG ENAILRANLL KQSEANNAAL ESLNNSIKQK
     QDEYQRKLEE LKKEIEYAKT KSLFHEREAQ DAIETMKKMK RDVKNSPIMK KSHEEDGDNK
     LLSSSDQLAK STKHAAKNSP SKKKRKTSVA TAEDASTDSV SSSIAISDAS LSLSLMKDLL
     SLQKREDLYF SSRTLAYVFG GCMHSLETIE GEEEGECLFN NLKALIYSPD LSMDSSNYVQ
     SVVQTSSSIL NYSMKKLLYN ASFAITSLFN ALLILDPKSS TFIFQENVVS LISGFLLKEY
     EKSNFLDSKF YVLIDFLYLY LSIARESADD FANITKAVDP SLFESCIRVQ NAPSLIKCGV
     CLIISSTTPS FCASVNLLNA DDKSQESLMQ LFTTMAHILV VTTRERINFP ELNEWITLHR
     FVISFFTVFI QMSGNIGKEI LKVCNPLIVC IGLAITWYHQ QLLSSMYPQN ECVEILVSLV
     RLLYILSSED LSSKFMLAEN ALQPRFVYAI ACCAFGDTEQ KAFGNLGEEM YFLTTELLEV
     CVSPEELEQL YTNF