ID   RAD52_ASHGO             Reviewed;         435 AA.
AC   Q756F4;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=DNA repair and recombination protein RAD52;
GN   Name=RAD52; OrderedLocusNames=AER306C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in DNA double-strand break (DSB) repair and
CC       recombination. Promotes the annealing of complementary single-stranded
CC       DNA and by stimulation of the RAD51 recombinase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Part of a complex that includes RAD51, RAD52 and RAD59.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RAD52 family. {ECO:0000305}.
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DR   EMBL; AE016818; AAS52986.1; -; Genomic_DNA.
DR   RefSeq; NP_985162.1; NM_210516.1.
DR   AlphaFoldDB; Q756F4; -.
DR   SMR; Q756F4; -.
DR   STRING; 33169.AAS52986; -.
DR   EnsemblFungi; AAS52986; AAS52986; AGOS_AER306C.
DR   GeneID; 4621375; -.
DR   KEGG; ago:AGOS_AER306C; -.
DR   eggNOG; KOG4141; Eukaryota.
DR   HOGENOM; CLU_011431_3_2_1; -.
DR   InParanoid; Q756F4; -.
DR   OMA; LDDSFMF; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR   GO; GO:0000228; C:nuclear chromosome; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000150; F:DNA strand exchange activity; IEA:EnsemblFungi.
DR   GO; GO:1990814; F:DNA/DNA annealing activity; IEA:EnsemblFungi.
DR   GO; GO:0006277; P:DNA amplification; IEA:EnsemblFungi.
DR   GO; GO:0000730; P:DNA recombinase assembly; IEA:EnsemblFungi.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IEA:EnsemblFungi.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:0045002; P:double-strand break repair via single-strand annealing; IBA:GO_Central.
DR   GO; GO:0000709; P:meiotic joint molecule formation; IEA:EnsemblFungi.
DR   GO; GO:0043504; P:mitochondrial DNA repair; IEA:EnsemblFungi.
DR   GO; GO:0006312; P:mitotic recombination; IBA:GO_Central.
DR   GO; GO:1904877; P:positive regulation of DNA ligase activity; IEA:EnsemblFungi.
DR   GO; GO:0006301; P:postreplication repair; IEA:EnsemblFungi.
DR   GO; GO:0000722; P:telomere maintenance via recombination; IEA:EnsemblFungi.
DR   Gene3D; 3.30.390.80; -; 1.
DR   InterPro; IPR004585; DNA_recomb/repair_Rad52.
DR   InterPro; IPR041247; Rad52_fam.
DR   InterPro; IPR007232; Rad52_Rad59_Rad22.
DR   InterPro; IPR042525; Rad52_Rad59_Rad22_sf.
DR   PANTHER; PTHR12132; PTHR12132; 2.
DR   Pfam; PF04098; Rad52_Rad22; 1.
DR   TIGRFAMs; TIGR00607; rad52; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; DNA-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..435
FT                   /note="DNA repair and recombination protein RAD52"
FT                   /id="PRO_0000173884"
FT   DNA_BIND        128..132
FT                   /evidence="ECO:0000250"
FT   REGION          161..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          349..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        170..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..280
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        377..392
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   435 AA;  47529 MW;  342E4F41DAF79BC5 CRC64;
     MADDKKGQMG NVDDIQAKLD KRLGPEYISK RVGHGTTRVA YIEGWKAINL ANQIFGFNGW
     SSEVKSVTVD FMDERQGRFT IGCTAVVRVT LSDGTFREDI GYGTVENDRR KSGAFERAKK
     SAVTDALKRS LRGFGNALGN CLYDKDFLSK IDKVKFEPPD FDEGNLFRAT DENNELSRAN
     TVTDHSEGPA PKKRNAPLPP APRPGAMRPE AAHAAPAPSE PPLERPRSSE NDQEDLLDDS
     FMFSDELQDD DLINIGSAKK APSGVPRPAP PPPPRAWPPQ DAPVAFVTAK AAPDLQAHGP
     VPPTHLFDPK FQAQSIRHTV DQTTSAHVKL SVLREKGIDQ ARDDIYSKFA PKGKILPPPD
     TATDPDPTLA ARPALSAPQN LPTNTSSIQR PTMIELPKLH FPQPTAVPLP NVPASRREVG
     RPKQSPPSLR KPPPQ