ID   RAD52_EMENI             Reviewed;         582 AA.
AC   Q96UP6; C8V8T5; Q5B4X3;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=DNA repair and recombination protein radC;
DE   AltName: Full=RAD52 homolog;
GN   Name=radC; ORFNames=AN4407;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Ka S.-H., Lee N.-S., Kafer E., Chae S.-K.;
RT   "A RAD52 homolog in Aspergillus nidulans as an interactor of UVSC and
RT   characterization of its null mutant.";
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Involved in DNA double-strand break (DSB) repair and
CC       recombination. Promotes the annealing of complementary single-stranded
CC       DNA and by stimulation of the RAD51 recombinase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Part of a complex that includes RAD51, RAD52 and RAD59.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RAD52 family. {ECO:0000305}.
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DR   EMBL; AY032591; AAK50143.1; -; Genomic_DNA.
DR   EMBL; AACD01000076; EAA60324.1; -; Genomic_DNA.
DR   EMBL; BN001303; CBF77590.1; -; Genomic_DNA.
DR   RefSeq; XP_662011.1; XM_656919.1.
DR   AlphaFoldDB; Q96UP6; -.
DR   SMR; Q96UP6; -.
DR   STRING; 162425.CADANIAP00006050; -.
DR   EnsemblFungi; CBF77590; CBF77590; ANIA_04407.
DR   EnsemblFungi; EAA60324; EAA60324; AN4407.2.
DR   GeneID; 2872207; -.
DR   KEGG; ani:AN4407.2; -.
DR   eggNOG; KOG4141; Eukaryota.
DR   HOGENOM; CLU_011431_4_0_1; -.
DR   InParanoid; Q96UP6; -.
DR   OMA; QFDPHAE; -.
DR   OrthoDB; 1572665at2759; -.
DR   Proteomes; UP000000560; Chromosome III.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000730; P:DNA recombinase assembly; IEA:InterPro.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:0045002; P:double-strand break repair via single-strand annealing; IBA:GO_Central.
DR   GO; GO:0006312; P:mitotic recombination; IBA:GO_Central.
DR   Gene3D; 3.30.390.80; -; 1.
DR   InterPro; IPR004585; DNA_recomb/repair_Rad52.
DR   InterPro; IPR041247; Rad52_fam.
DR   InterPro; IPR007232; Rad52_Rad59_Rad22.
DR   InterPro; IPR042525; Rad52_Rad59_Rad22_sf.
DR   PANTHER; PTHR12132; PTHR12132; 1.
DR   Pfam; PF04098; Rad52_Rad22; 1.
DR   TIGRFAMs; TIGR00607; rad52; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; DNA-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..582
FT                   /note="DNA repair and recombination protein radC"
FT                   /id="PRO_0000173887"
FT   DNA_BIND        146..150
FT                   /evidence="ECO:0000250"
FT   REGION          194..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          310..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          485..582
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        310..365
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        514..528
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   582 AA;  61912 MW;  81BD7CA97A91B516 CRC64;
     MPDATGVIAR NPFEEAPSRL NQYTPEEAAA LQARLEKKLG PEYISSRPGA AGLKVHYLAA
     DKCINLANEV FGFNGWSSSI QNIQIDFVDE SPNTGKVSLG LSVIVRVTLK DGAYHEDLGY
     GHIENCKGKA AAFEKAKKEA TTDALKRALR NFGNVLGNCI YDKDYISKVS KLKTVPSKLD
     VGDLHRHPDF APIKKEPMRV KPSLEDDDLP PNPSIAGRNT STNSAADMDA EFGSDVFDEA
     DFNVGEGEYP DGIVAEDTQK RHQPPTPVGR PNAHLNLPKH ALGAQASGNQ HVVTPSKPER
     PMNLAPAGRQ IPNQALNNRP FPPPAQNQYT NQRQSVPLPG SNGGLQNGRS IPLGQRASNG
     MATGSDAGAQ VPIKQEHGAK QPNPAPQNTA VPATPGINGQ GPPVVGFLSA RGADMLRENP
     HSAATVAPAF NPHAESPSIR KTAGVDHTKS IPISKPMLAG SASPLSNQTR DFINPSAEMH
     RKIGAPSGSV VGGPMNRGPS VSSYRPLTRP NVDPKAAAQN NTAAANRMAP NMNGKRPPLN
     DVTNETLPGG NGCTPAPGLN DPKRAKYDES MSAQQHQQQH QH