RAD52_KLULA
ID RAD52_KLULA Reviewed; 436 AA.
AC P41768; Q6CWS9;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2004, sequence version 2.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=DNA repair and recombination protein RAD52;
GN Name=RAD52; OrderedLocusNames=KLLA0B01782g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8370524; DOI=10.1101/gad.7.9.1755;
RA Milne G.T., Weaver D.T.;
RT "Dominant negative alleles of RAD52 reveal a DNA repair/recombination
RT complex including Rad51 and Rad52.";
RL Genes Dev. 7:1755-1765(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in DNA double-strand break (DSB) repair and
CC recombination. Promotes the annealing of complementary single-stranded
CC DNA and by stimulation of the RAD51 recombinase (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Part of a complex that includes RAD51, RAD52 and RAD59.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RAD52 family. {ECO:0000305}.
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DR EMBL; X75086; CAA52978.1; -; Genomic_DNA.
DR EMBL; CR382122; CAH02003.1; -; Genomic_DNA.
DR RefSeq; XP_451610.1; XM_451610.1.
DR AlphaFoldDB; P41768; -.
DR SMR; P41768; -.
DR STRING; 28985.XP_451610.1; -.
DR EnsemblFungi; CAH02003; CAH02003; KLLA0_B01782g.
DR GeneID; 2896980; -.
DR KEGG; kla:KLLA0_B01782g; -.
DR eggNOG; KOG4141; Eukaryota.
DR HOGENOM; CLU_011431_3_2_1; -.
DR InParanoid; P41768; -.
DR OMA; LDDSFMF; -.
DR Proteomes; UP000000598; Chromosome B.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0000228; C:nuclear chromosome; IEA:EnsemblFungi.
DR GO; GO:0000150; F:DNA strand exchange activity; IEA:EnsemblFungi.
DR GO; GO:1990814; F:DNA/DNA annealing activity; IEA:EnsemblFungi.
DR GO; GO:0006277; P:DNA amplification; IEA:EnsemblFungi.
DR GO; GO:0000730; P:DNA recombinase assembly; IEA:EnsemblFungi.
DR GO; GO:0000727; P:double-strand break repair via break-induced replication; IEA:EnsemblFungi.
DR GO; GO:0045002; P:double-strand break repair via single-strand annealing; IEA:EnsemblFungi.
DR GO; GO:0000709; P:meiotic joint molecule formation; IEA:EnsemblFungi.
DR GO; GO:0043504; P:mitochondrial DNA repair; IEA:EnsemblFungi.
DR GO; GO:1904877; P:positive regulation of DNA ligase activity; IEA:EnsemblFungi.
DR GO; GO:0006301; P:postreplication repair; IEA:EnsemblFungi.
DR GO; GO:0000722; P:telomere maintenance via recombination; IEA:EnsemblFungi.
DR Gene3D; 3.30.390.80; -; 1.
DR InterPro; IPR004585; DNA_recomb/repair_Rad52.
DR InterPro; IPR041247; Rad52_fam.
DR InterPro; IPR007232; Rad52_Rad59_Rad22.
DR InterPro; IPR042525; Rad52_Rad59_Rad22_sf.
DR PANTHER; PTHR12132; PTHR12132; 1.
DR Pfam; PF04098; Rad52_Rad22; 1.
DR TIGRFAMs; TIGR00607; rad52; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA recombination; DNA repair; DNA-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..436
FT /note="DNA repair and recombination protein RAD52"
FT /id="PRO_0000173888"
FT DNA_BIND 127..131
FT /evidence="ECO:0000250"
FT REGION 180..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 207
FT /note="A -> P (in Ref. 1; CAA52978)"
FT /evidence="ECO:0000305"
FT CONFLICT 226..227
FT /note="KA -> I (in Ref. 1; CAA52978)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 436 AA; 47751 MW; 65FDF3F2FD1DD293 CRC64;
MEDTGSGKNG KDDIQTKLDK KLGPEYISKR VGFGSSRVAY IEGWKAINLA NQIFGYDGWS
TEVKNVTIDF LDERQGRFSI GCTAIVRVSL ADGTFREDIG YGTVENERRK ASAFERAKKS
AVTDALKRSL RGFGNALGNC LYDKDFLAKI DKVKFDPPDF DEGNLFRPAD ELSEMSRSNM
VGDAHTEGPS LKKRSLTNED RNAVPSAPAQ QTYRSNNHTT QKRAPKAQAV TASASPNEET
SNQQQDPDDL LDDSFMFSDE IQDDDLLNMN TTTNNKNSTN SSTTTTTISD EATGIISPVT
FVTAKAATSL QHKDPIPSGS MFDPKFQAQS IRHTVDQSVS TPVRATILKE KGLDSDRSSI
YSKFAPKGKE LSGTTTNSEP YVAAPQTSAT ESNRSTPTRS NAQLAGPQPA PQLQGPQRTQ
LGRPRMLQQP NRRNVS
