ID   RAD52_NEUCR             Reviewed;         600 AA.
AC   Q9HGI2; Q1K793;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=DNA repair and recombination protein mus-11;
DE   AltName: Full=Mutagen-sensitive protein 11;
DE   AltName: Full=RAD52 homolog;
GN   Name=mus-11; Synonyms=rad52; ORFNames=B8L3.020, NCU04275;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11129042; DOI=10.1007/s004380000342;
RA   Sakuraba Y., Schroeder A.L., Ishii C., Inoue H.;
RT   "A Neurospora double-strand-break repair gene, mus-11, encodes a RAD52
RT   homologue and is inducible by mutagens.";
RL   Mol. Gen. Genet. 264:392-401(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in DNA double-strand break (DSB) repair and
CC       recombination. Promotes the annealing of complementary single-stranded
CC       DNA and by stimulation of the mei-3/rad51 recombinase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Part of a complex that includes mei-3/rad51 and mus-11/rad52.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RAD52 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA31829.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AB039859; BAB13343.1; -; Genomic_DNA.
DR   EMBL; AL513462; CAC28736.1; -; Genomic_DNA.
DR   EMBL; CM002240; EAA31829.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_961065.2; XM_955972.2.
DR   AlphaFoldDB; Q9HGI2; -.
DR   SMR; Q9HGI2; -.
DR   STRING; 5141.EFNCRP00000003767; -.
DR   EnsemblFungi; EAA31829; EAA31829; NCU04275.
DR   GeneID; 3877219; -.
DR   KEGG; ncr:NCU04275; -.
DR   HOGENOM; CLU_011431_4_0_1; -.
DR   InParanoid; Q9HGI2; -.
DR   OMA; QFDPHAE; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000730; P:DNA recombinase assembly; IEA:InterPro.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:0045002; P:double-strand break repair via single-strand annealing; IBA:GO_Central.
DR   GO; GO:0006312; P:mitotic recombination; IBA:GO_Central.
DR   Gene3D; 3.30.390.80; -; 1.
DR   InterPro; IPR004585; DNA_recomb/repair_Rad52.
DR   InterPro; IPR041247; Rad52_fam.
DR   InterPro; IPR007232; Rad52_Rad59_Rad22.
DR   InterPro; IPR042525; Rad52_Rad59_Rad22_sf.
DR   PANTHER; PTHR12132; PTHR12132; 1.
DR   Pfam; PF04098; Rad52_Rad22; 1.
DR   TIGRFAMs; TIGR00607; rad52; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; DNA-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..600
FT                   /note="DNA repair and recombination protein mus-11"
FT                   /id="PRO_0000173890"
FT   DNA_BIND        148..152
FT                   /evidence="ECO:0000250"
FT   REGION          268..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          387..600
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        268..342
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        425..439
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        499..515
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        535..561
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        573..587
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   600 AA;  63495 MW;  147AEE5365789AC0 CRC64;
     MPAVGDQHKL IANPFEEPQR RISEYTAQEI ATLQSRLEKQ LGPEYLSSRA GPSGQKVHYI
     SSEKCIQLAN EVFGFNGWSS SIQNIQVDFV DEHPQTLKIN MGISVIMRVT LRDGTYHEDL
     GYGHIENCKG KAAAFEKAKK EATTDALKRA LRQFGNVLGN CIYDKQYLAK VTKMKVEPTK
     FAEDNLHRHS DFVKKEPVEA DIMKVDSVGA GARPPALGNE ESFEDLLGEL DEADFNMADE
     GHPDEVVLPQ AVHNSLNDKP VHQQLTNLNP QAQQSRPLSR SGSTGSLNTR QQPQNSHQFT
     ARAQSRPPQQ QLNSNQSRPM GQPVNNSSNA NTPNNPQNYT TPQKPAPAAP APQAGAAVAP
     APETVGFFSA KAVTQLPEEA LASGQVAPKP GLAFNPHAES PSIRKTPGID HTKSKPLARN
     GQHVPPAKTT ETEAEPSTSL SRPAGAHAAS RPVTMNEARS ASGSFSRAGP PMGGNAGNMG
     KPNVVNPQLD HTRRIGAPGM SGFSSSPSTN RGQYRPLTMK RPAPVVGGGA GQTKDGNGDS
     ATTTTIAANT TAGSATGGNA APSAGNGGRV PLTDMSANAS NATAAGAATS GPEVKRQRLA