位置:首页 > 蛋白库 > RAD55_YEAST
RAD55_YEAST
ID   RAD55_YEAST             Reviewed;         406 AA.
AC   P38953; D6VS62;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 181.
DE   RecName: Full=DNA repair protein RAD55;
GN   Name=RAD55; OrderedLocusNames=YDR076W; ORFNames=D4426;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204510 / AB320;
RX   PubMed=8181742; DOI=10.1016/0378-1119(94)90362-x;
RA   Lovett S.T.;
RT   "Sequence of the RAD55 gene of Saccharomyces cerevisiae: similarity of
RT   RAD55 to prokaryotic RecA and other RecA-like proteins.";
RL   Gene 142:103-106(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RA   Kuwahara S., Yoshima T., Fong J., Ogawa T.;
RT   "Cloning of the RAD55 gene and identification of its gene product in
RT   Saccharomyces cerevisiae.";
RL   Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 96604 / S288c / FY1679;
RX   PubMed=7483840; DOI=10.1002/yea.320110708;
RA   Coster F., Jonniaux J.-L., Goffeau A.;
RT   "Analysis of a 32.8 kb segment of yeast chromosome IV reveals 21 open
RT   reading frames, including TPS2, PPH3, RAD55, SED1, PDC2, AFR1, SSS1, SLU7
RT   and a tRNA for arginine.";
RL   Yeast 11:673-679(1995).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169867;
RA   Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA   Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA   Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA   Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA   Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA   Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA   Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA   Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA   Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA   Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA   Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA   Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA   Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA   Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA   Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA   Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA   Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA   Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA   Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA   Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA   Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA   Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA   Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA   Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA   Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA   Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA   Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA   Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA   Mewes H.-W., Zollner A., Zaccaria P.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL   Nature 387:75-78(1997).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [7]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- FUNCTION: Required for radiation resistance and meiotic viability and
CC       presumably acts in recombination and recombinational DNA repair
CC       pathways.
CC   -!- INTERACTION:
CC       P38953; P25454: RAD51; NbExp=6; IntAct=EBI-14737, EBI-14709;
CC       P38953; P25301: RAD57; NbExp=9; IntAct=EBI-14737, EBI-14744;
CC       P38953; P12954: SRS2; NbExp=4; IntAct=EBI-14737, EBI-18110;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- MISCELLANEOUS: Present with 1050 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the RecA family. RAD55 subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z46796; CAA86798.1; -; Genomic_DNA.
DR   EMBL; D10481; BAA01284.1; -; Genomic_DNA.
DR   EMBL; U01144; AAA19688.1; -; Genomic_DNA.
DR   EMBL; X82086; CAA57603.1; -; Genomic_DNA.
DR   EMBL; Z74372; CAA98895.1; -; Genomic_DNA.
DR   EMBL; AY723773; AAU09690.1; -; Genomic_DNA.
DR   EMBL; BK006938; DAA11922.1; -; Genomic_DNA.
DR   PIR; S48763; S48763.
DR   RefSeq; NP_010361.3; NM_001180384.3.
DR   AlphaFoldDB; P38953; -.
DR   BioGRID; 32131; 272.
DR   ComplexPortal; CPX-3139; RAD55-RAD57 complex.
DR   DIP; DIP-1554N; -.
DR   IntAct; P38953; 12.
DR   MINT; P38953; -.
DR   STRING; 4932.YDR076W; -.
DR   iPTMnet; P38953; -.
DR   MaxQB; P38953; -.
DR   PaxDb; P38953; -.
DR   PRIDE; P38953; -.
DR   EnsemblFungi; YDR076W_mRNA; YDR076W; YDR076W.
DR   GeneID; 851648; -.
DR   KEGG; sce:YDR076W; -.
DR   SGD; S000002483; RAD55.
DR   VEuPathDB; FungiDB:YDR076W; -.
DR   eggNOG; ENOG502RTRR; Eukaryota.
DR   HOGENOM; CLU_053754_0_0_1; -.
DR   InParanoid; P38953; -.
DR   OMA; TIHELKC; -.
DR   BioCyc; YEAST:G3O-29681-MON; -.
DR   PRO; PR:P38953; -.
DR   Proteomes; UP000002311; Chromosome IV.
DR   RNAct; P38953; protein.
DR   GO; GO:0033063; C:Rad51B-Rad51C-Rad51D-XRCC2 complex; IBA:GO_Central.
DR   GO; GO:0033065; C:Rad51C-XRCC3 complex; IBA:GO_Central.
DR   GO; GO:0005657; C:replication fork; IBA:GO_Central.
DR   GO; GO:0033062; C:Rhp55-Rhp57 complex; IDA:SGD.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008094; F:ATP-dependent activity, acting on DNA; ISS:SGD.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0000730; P:DNA recombinase assembly; IMP:SGD.
DR   GO; GO:0006302; P:double-strand break repair; IMP:ComplexPortal.
DR   GO; GO:0042275; P:error-free postreplication DNA repair; IDA:ComplexPortal.
DR   GO; GO:0030491; P:heteroduplex formation; IDA:SGD.
DR   GO; GO:0000707; P:meiotic DNA recombinase assembly; IMP:SGD.
DR   GO; GO:1903112; P:positive regulation of single-strand break repair via homologous recombination; IDA:ComplexPortal.
DR   GO; GO:0007131; P:reciprocal meiotic recombination; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020588; RecA_ATP-bd.
DR   Pfam; PF08423; Rad51; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50162; RECA_2; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; DNA damage; DNA repair; Nucleotide-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..406
FT                   /note="DNA repair protein RAD55"
FT                   /id="PRO_0000122954"
FT   REGION          385..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         43..50
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        110
FT                   /note="F -> L (in Ref. 2; AAA19688)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        197
FT                   /note="F -> N (in Ref. 2; AAA19688)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   406 AA;  46350 MW;  8EA49831F7F3E098 CRC64;
     MSLGIPLSQL IVESPKPLSS GITGLDEILN LGFQARSIYE IFGPPGIGKT NFGIQLVCNS
     LEGIQQSEIN DDKILWIETF QEMPINILRE RFQKFKIVEE NVKRVRITKF GQLLYFFQNL
     FKLSQSVRYK LVIIDGFSQL VCDHLCTLSK RGGGMIDKTI HELKCRHLIL IFTVMTKYTH
     STGSTIIVLN DCMNTAFQSN EFESLEEYYE ILDDGSNFFV NSNNERRKNN VHILKSALVA
     NIAMGSKDST WEVFLRDRIG LFRDWNEQVD ETVFVKSKRV KASSSQSNEG CTTIKEMRIN
     KRNFENLRIA IVFNLHGEDR KREGRNLKRS RSSDDRNYIV KFDFDKATGQ LRDIIDLKPD
     TANIASFPTL STSSSSCSQV FNNIDSNDNP LPNAEGKEEI IYDSEG
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024