ID   RAD59_ASHGO             Reviewed;         204 AA.
AC   Q757G7;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=DNA repair protein RAD59;
GN   Name=RAD59; OrderedLocusNames=AER046W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in the repair of double-strand breaks in DNA during
CC       vegetative growth via recombination and single-strand annealing.
CC       Anneals complementary single-stranded DNA (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RAD51 and RAD52. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RAD52 family. {ECO:0000305}.
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DR   EMBL; AE016818; AAS52730.1; -; Genomic_DNA.
DR   RefSeq; NP_984906.1; NM_210260.1.
DR   AlphaFoldDB; Q757G7; -.
DR   SMR; Q757G7; -.
DR   STRING; 33169.AAS52730; -.
DR   EnsemblFungi; AAS52730; AAS52730; AGOS_AER046W.
DR   GeneID; 4621108; -.
DR   KEGG; ago:AGOS_AER046W; -.
DR   eggNOG; KOG4141; Eukaryota.
DR   HOGENOM; CLU_091426_0_0_1; -.
DR   InParanoid; Q757G7; -.
DR   OMA; WSVQRIG; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0006277; P:DNA amplification; IEA:EnsemblFungi.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:0045002; P:double-strand break repair via single-strand annealing; IBA:GO_Central.
DR   GO; GO:0043504; P:mitochondrial DNA repair; IEA:EnsemblFungi.
DR   GO; GO:0006312; P:mitotic recombination; IBA:GO_Central.
DR   GO; GO:2000278; P:regulation of DNA biosynthetic process; IEA:EnsemblFungi.
DR   GO; GO:0000722; P:telomere maintenance via recombination; IEA:EnsemblFungi.
DR   Gene3D; 3.30.390.80; -; 1.
DR   InterPro; IPR041247; Rad52_fam.
DR   InterPro; IPR007232; Rad52_Rad59_Rad22.
DR   InterPro; IPR042525; Rad52_Rad59_Rad22_sf.
DR   InterPro; IPR016810; Rad59.
DR   PANTHER; PTHR12132; PTHR12132; 1.
DR   PANTHER; PTHR12132:SF2; PTHR12132:SF2; 1.
DR   Pfam; PF04098; Rad52_Rad22; 1.
DR   PIRSF; PIRSF022936; RAD59_fungi; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Nucleus; Reference proteome.
FT   CHAIN           1..204
FT                   /note="DNA repair protein RAD59"
FT                   /id="PRO_0000173894"
SQ   SEQUENCE   204 AA;  22881 MW;  AAD084FB10558DDB CRC64;
     MSDYTNVSWD NVTYYGGNGV ALDELELKVS WHNRPASSWS VRRIGALQHK IEQYTFKIYH
     VNRYGKHSLS QVIPTHVLIQ FANEAFGYNG WSSAVEEVLI TDVKQRERVR DGAAIELYTV
     TAEARVKLTL QDGTNTEATG LSKITLPSKG DAYGKAKKEA SADALKRCLL SFEGIVIEHE
     QKVASNYYTD GEFGSRKAGD KRDR