ID   RAD59_KLULA             Reviewed;         209 AA.
AC   Q9HEU2; Q6CPF7;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=DNA repair protein RAD59;
GN   Name=RAD59; OrderedLocusNames=KLLA0E05203g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11525403; DOI=10.1007/s002940100212;
RA   van den Bosch M., Zonneveld J.B.M., Lohman P.H.M., Pastink A.;
RT   "Identification and characterization of the RAD59 homolog of Kluyveromyces
RT   lactis.";
RL   Curr. Genet. 39:305-310(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in the repair of double-strand breaks in DNA during
CC       vegetative growth via recombination and single-strand annealing.
CC       Anneals complementary single-stranded DNA (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RAD51 and RAD52. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RAD52 family. {ECO:0000305}.
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DR   EMBL; AF324456; AAG45224.1; -; Genomic_DNA.
DR   EMBL; CR382125; CAG99269.1; -; Genomic_DNA.
DR   RefSeq; XP_454182.1; XM_454182.1.
DR   AlphaFoldDB; Q9HEU2; -.
DR   SMR; Q9HEU2; -.
DR   STRING; 28985.XP_454182.1; -.
DR   EnsemblFungi; CAG99269; CAG99269; KLLA0_E05259g.
DR   GeneID; 2894107; -.
DR   KEGG; kla:KLLA0_E05259g; -.
DR   eggNOG; KOG4141; Eukaryota.
DR   HOGENOM; CLU_091426_0_0_1; -.
DR   InParanoid; Q9HEU2; -.
DR   OMA; WSVQRIG; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006277; P:DNA amplification; IEA:EnsemblFungi.
DR   GO; GO:0045002; P:double-strand break repair via single-strand annealing; IEA:EnsemblFungi.
DR   GO; GO:0043504; P:mitochondrial DNA repair; IEA:EnsemblFungi.
DR   GO; GO:2000278; P:regulation of DNA biosynthetic process; IEA:EnsemblFungi.
DR   GO; GO:0000722; P:telomere maintenance via recombination; IEA:EnsemblFungi.
DR   Gene3D; 3.30.390.80; -; 1.
DR   InterPro; IPR041247; Rad52_fam.
DR   InterPro; IPR007232; Rad52_Rad59_Rad22.
DR   InterPro; IPR042525; Rad52_Rad59_Rad22_sf.
DR   InterPro; IPR016810; Rad59.
DR   PANTHER; PTHR12132; PTHR12132; 1.
DR   PANTHER; PTHR12132:SF2; PTHR12132:SF2; 1.
DR   Pfam; PF04098; Rad52_Rad22; 1.
DR   PIRSF; PIRSF022936; RAD59_fungi; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Nucleus; Reference proteome.
FT   CHAIN           1..209
FT                   /note="DNA repair protein RAD59"
FT                   /id="PRO_0000173896"
SQ   SEQUENCE   209 AA;  23859 MW;  5CBB4BC5BBE1335E CRC64;
     MSRYTDISYE GTSYTVNTGL DIKDFQIEED WYNRPASEWS VKRIGQLQGK VEQYTYRIYH
     SNKYGKHNLA RLIPGHVLIS FANECFGYDG WSSEVEEITS LEHTENAASE DKRESHTVLA
     EARVKLVLKD DTYTFAGGFG KSTMPFKGEA FAKAKKEAIT DALKNCLLGF EKVILDHEIK
     IKQNYYVDGV FKAEMSKIEG KTSIPRTVR