RAD59_YEAST
ID RAD59_YEAST Reviewed; 238 AA.
AC Q12223; D6VRT7;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=DNA repair protein RAD59;
GN Name=RAD59; OrderedLocusNames=YDL059C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8769646; DOI=10.1101/gad.10.16.2025;
RA Bai Y., Symington L.S.;
RT "A Rad52 homolog is required for RAD51-independent mitotic recombination in
RT Saccharomyces cerevisiae.";
RL Genes Dev. 10:2025-2037(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP INTERACTION WITH RAD51 AND RAD52.
RX PubMed=13679150; DOI=10.1016/s1568-7864(03)00121-6;
RA Davis A.P., Symington L.S.;
RT "The Rad52-Rad59 complex interacts with Rad51 and replication protein A.";
RL DNA Repair 2:1127-1134(2003).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Involved in the repair of double-strand breaks in DNA during
CC vegetative growth via recombination and single-strand annealing.
CC Anneals complementary single-stranded DNA.
CC -!- SUBUNIT: Interacts with RAD51 and RAD52. {ECO:0000269|PubMed:13679150}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- MISCELLANEOUS: Present with 468 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the RAD52 family. {ECO:0000305}.
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DR EMBL; U53668; AAB66660.1; -; Genomic_DNA.
DR EMBL; Z74107; CAA98622.1; -; Genomic_DNA.
DR EMBL; AY693025; AAT93044.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA11797.1; -; Genomic_DNA.
DR PIR; S67594; S67594.
DR RefSeq; NP_010224.1; NM_001180118.1.
DR AlphaFoldDB; Q12223; -.
DR SMR; Q12223; -.
DR BioGRID; 31999; 144.
DR DIP; DIP-2068N; -.
DR IntAct; Q12223; 68.
DR MINT; Q12223; -.
DR STRING; 4932.YDL059C; -.
DR iPTMnet; Q12223; -.
DR MaxQB; Q12223; -.
DR PaxDb; Q12223; -.
DR PRIDE; Q12223; -.
DR TopDownProteomics; Q12223; -.
DR EnsemblFungi; YDL059C_mRNA; YDL059C; YDL059C.
DR GeneID; 851500; -.
DR KEGG; sce:YDL059C; -.
DR SGD; S000002217; RAD59.
DR VEuPathDB; FungiDB:YDL059C; -.
DR eggNOG; KOG4141; Eukaryota.
DR GeneTree; ENSGT00390000008766; -.
DR HOGENOM; CLU_091426_0_0_1; -.
DR InParanoid; Q12223; -.
DR OMA; WSVQRIG; -.
DR BioCyc; YEAST:G3O-29475-MON; -.
DR PRO; PR:Q12223; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q12223; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005759; C:mitochondrial matrix; IDA:SGD.
DR GO; GO:0005634; C:nucleus; IGI:SGD.
DR GO; GO:0006277; P:DNA amplification; IMP:SGD.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0045002; P:double-strand break repair via single-strand annealing; IGI:SGD.
DR GO; GO:0043504; P:mitochondrial DNA repair; IMP:SGD.
DR GO; GO:0006312; P:mitotic recombination; IBA:GO_Central.
DR GO; GO:2000278; P:regulation of DNA biosynthetic process; IGI:SGD.
DR GO; GO:0000722; P:telomere maintenance via recombination; IMP:SGD.
DR Gene3D; 3.30.390.80; -; 1.
DR InterPro; IPR041247; Rad52_fam.
DR InterPro; IPR007232; Rad52_Rad59_Rad22.
DR InterPro; IPR042525; Rad52_Rad59_Rad22_sf.
DR InterPro; IPR016810; Rad59.
DR PANTHER; PTHR12132; PTHR12132; 1.
DR PANTHER; PTHR12132:SF2; PTHR12132:SF2; 1.
DR Pfam; PF04098; Rad52_Rad22; 1.
DR PIRSF; PIRSF022936; RAD59_fungi; 1.
PE 1: Evidence at protein level;
KW DNA damage; DNA recombination; DNA repair; Nucleus; Reference proteome.
FT CHAIN 1..238
FT /note="DNA repair protein RAD59"
FT /id="PRO_0000173897"
SQ SEQUENCE 238 AA; 26630 MW; 3EC4896FBE965793 CRC64;
MTIQAKPSSS ISYDSTTYGT APGLDIKEFQ IIEDWNGRPA SAWSVQRIGL LQSKIERYTY
NIYHNNKYGK HNLSKLIPGH ALIQFANETF GYDGWRMDVI DVEARECQPF TAVNNGENTN
TSEVKYTVVA EAQVKVTLKD GTNTQCGGLG RITLSSRGEC YNRSKKEAVG DALKKALLSF
EKIILDYETK ITNNYYVDGL YGSKKIKNEA NTNYNLLSAT NSKPTFIKLE DAKGTHIK
