RAD7_SCHPO
ID RAD7_SCHPO Reviewed; 563 AA.
AC O74999;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=DNA repair protein rhp7;
DE AltName: Full=RAD7 homolog;
GN Name=rhp7; ORFNames=SPCC330.02, SPCC613.14;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION.
RX PubMed=10446227; DOI=10.1093/nar/27.17.3410;
RA Lombaerts M., Peltola P.H., Visse R., den Dulk H., Brandsma J.A.,
RA Brouwer J.;
RT "Characterization of the rhp7(+) and rhp16(+) genes in Schizosaccharomyces
RT pombe.";
RL Nucleic Acids Res. 27:3410-3416(1999).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Involved in global genome repair (GGR) via nucleotide
CC excision repair (NER), in conjunction with rhp16, after UV irradiation.
CC {ECO:0000269|PubMed:10446227}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the RAD7 family. {ECO:0000305}.
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DR EMBL; CU329672; CAA21066.1; -; Genomic_DNA.
DR PIR; T41312; T41312.
DR RefSeq; NP_587702.1; NM_001022697.2.
DR AlphaFoldDB; O74999; -.
DR SMR; O74999; -.
DR BioGRID; 275666; 21.
DR STRING; 4896.SPCC330.02.1; -.
DR MaxQB; O74999; -.
DR PaxDb; O74999; -.
DR PRIDE; O74999; -.
DR EnsemblFungi; SPCC330.02.1; SPCC330.02.1:pep; SPCC330.02.
DR GeneID; 2539094; -.
DR KEGG; spo:SPCC330.02; -.
DR PomBase; SPCC330.02; rhp7.
DR VEuPathDB; FungiDB:SPCC330.02; -.
DR eggNOG; KOG1947; Eukaryota.
DR HOGENOM; CLU_006598_2_1_1; -.
DR InParanoid; O74999; -.
DR OMA; PGQLANC; -.
DR PhylomeDB; O74999; -.
DR Reactome; R-SPO-163210; Formation of ATP by chemiosmotic coupling.
DR Reactome; R-SPO-8949613; Cristae formation.
DR PRO; PR:O74999; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0044732; C:mitotic spindle pole body; HDA:PomBase.
DR GO; GO:0000109; C:nucleotide-excision repair complex; IPI:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0006289; P:nucleotide-excision repair; IGI:PomBase.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR SMART; SM00367; LRR_CC; 8.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Nucleus; Reference proteome.
FT CHAIN 1..563
FT /note="DNA repair protein rhp7"
FT /id="PRO_0000363002"
FT REGION 1..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 563 AA; 62728 MW; 42425BBC9BD6489C CRC64;
MSSGSRVRGP NSALTEFLRS QGINASALGR ARPPRQSEES AGQSTGTESE VIQTPTSVEE
NNEDENSMST TTIEIPVVKR RNLRNQKKKK KTDEEAEDNE DTFSMNSRAG FSYKAREHTG
KLDFCAHCNC RFTITPYSKY SNSEKGWLCY PCSRGAEDRS VPELRTRKRK ALTRKKVAAA
TMDEEISVPK LQDLCIRVIA EYINDIEAFG DIGQVNMDKI SQIISKNRSL NDTTVKLFLS
GGQTELKLYD CSKITADSLF QIAQYCPNLQ TLHLTYCGQM QDQVLHFYAD HLTELTDVSF
QGAFLVSSSE WINFFKKRGS KLISLELTDT ARIHVSVINA IVDCCPNLIS LNLSRIFYLD
DECVRLLAGC RNLVSLKIES PGGIINDGSI LDVLNQIGSG LHTLSLSGCT KLTDEVLKQG
IGPCCGRLKH LNLSGLELLT DDEASIVFGE WKIQSGLETL SLRRCLSLGD KTVRAVLVNS
GHTLRTLDLN GMSFVTDEAL QYIVNFPLPM LKALDVSWIR GMNDKLVCDF ESKKPTLEKL
LVWGDNHVLM PSNRLLLIGR EVQ
